N-(叔丁氧羰基)抑胃酶氨酸合成路线 （共 49 条）
反应条件
1: NaBH4 / CH2Cl2; acetic acid 2: 1N NaOH / acetone View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 10 p. 1557 - 1560
反应条件
1: ethyl acetate 2: NaBH4 / CH2Cl2; acetic acid 3: 1N NaOH / acetone View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 10 p. 1557 - 1560
反应条件
1: 85 percent / p-TsOH*H2O / benzene / 1 h / Heating 2: 86 percent / DIBAH / diethyl ether; toluene / 0.25 h / -40 °C 3: 85 percent / 2-methyl-2-propanol; 5 percent NaH2PO4; 1M KMnO4 4: 80 percent / 85 percent AcOH / 0.67 h / 70 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 14, # 5 p. 549 - 554
反应条件
1: 86 percent / DIBAH / diethyl ether; toluene / 0.25 h / -40 °C 2: 85 percent / 2-methyl-2-propanol; 5 percent NaH2PO4; 1M KMnO4 3: 80 percent / 85 percent AcOH / 0.67 h / 70 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 14, # 5 p. 549 - 554
反应条件
1.1: trimethyloxonium tetrafluoroborate / petroleum ether / 1 h / 20 °C 1.2: 63 percent / K2CO3 / CH2Cl2; H2O / 24 h 2.1: toluene / 1 h / -15 °C 2.2: 59 percent / conc. HCl / toluene; methanol / 1 h / -15 °C 3.1: 85 percent / p-TsOH*H2O / benzene / 1 h / Heating 4.1: 86 percent / DIBAH / diethyl ether; toluene / 0.25 h / -40 °C 5.1: 85 percent / 2-methyl-2-propanol; 5 percent NaH2PO4; 1M KMnO4 6.1: 80 percent / 85 percent AcOH / 0.67 h / 70 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 14, # 5 p. 549 - 554
反应条件
1.1: ZnBr2 / tetrahydrofuran / 1.5 h / 0 °C 1.2: 75 percent / DIBALH / tetrahydrofuran; toluene / 1 h / -78 °C 2.1: 90 percent / TiCl3; aq. HCl / ethanol / 0.33 h / 20 °C 3.1: trimethyloxonium tetrafluoroborate / petroleum ether / 1 h / 20 °C 3.2: 63 percent / K2CO3 / CH2Cl2; H2O / 24 h 4.1: toluene / 1 h / -15 °C 4.2: 59 percent / conc. HCl / toluene; methanol / 1 h / -15 °C 5.1: 85 percent / p-TsOH*H2O / benzene / 1 h / Heating 6.1: 86 percent / DIBAH / diethyl ether; toluene / 0.25 h / -40 °C 7.1: 85 percent / 2-methyl-2-propanol; 5 percent NaH2PO4; 1M KMnO4 8.1: 80 percent / 85 percent AcOH / 0.67 h / 70 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 14, # 5 p. 549 - 554
反应条件
1.1: 90 percent / TiCl3; aq. HCl / ethanol / 0.33 h / 20 °C 2.1: trimethyloxonium tetrafluoroborate / petroleum ether / 1 h / 20 °C 2.2: 63 percent / K2CO3 / CH2Cl2; H2O / 24 h 3.1: toluene / 1 h / -15 °C 3.2: 59 percent / conc. HCl / toluene; methanol / 1 h / -15 °C 4.1: 85 percent / p-TsOH*H2O / benzene / 1 h / Heating 5.1: 86 percent / DIBAH / diethyl ether; toluene / 0.25 h / -40 °C 6.1: 85 percent / 2-methyl-2-propanol; 5 percent NaH2PO4; 1M KMnO4 7.1: 80 percent / 85 percent AcOH / 0.67 h / 70 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 14, # 5 p. 549 - 554
反应条件
1: DMAP / CHCl3 2: 89 percent / 1N NaOH / dioxane View Scheme
参考文献
Tetrahedron Letters, , vol. 40, # 4 p. 775 - 776
反应条件
1: 96 percent / NaIO4, RuCl3*xH2O / acetonitrile; CCl4; H2O / 48 h / Ambient temperature 2: Cs2CO3 / methanol / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 49, # 9 p. 1841 - 1852
反应条件
1.1: trifluoroacetic acid / dichloromethane / 0.33 h 1.2: 0.75 h / 0 - 20 °C / Inert atmosphere 2.1: sodium methylate / methanol / 1 h View Scheme
参考文献
Journal of Natural Products, , vol. 75, # 3 p. 425 - 431
