N-(叔丁氧羰基)抑胃酶氨酸合成路线 （共 49 条）
反应条件
1: H2 / Raney-Ni 2: aq. NaOH View Scheme
参考文献
Justus Liebigs Annalen der Chemie, , p. 2245 - 2250
反应条件
1: (i) iBu2AlH, toluene, hexane, (ii) /BRN= 506104/, nBuLi, iPr2NH, THF, hexane 2: dioxane; H2O / (alkaline hydrolysis) View Scheme
参考文献
Journal of Organic Chemistry, , vol. 43, p. 3624 - 3626
反应条件
sodium hydroxide; hydrogen bromide 1.) 75 deg C, 24 h, 2.) water, THF, rt, 94 h; Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 58, # 15 p. 4010 - 4012
反应条件
hydrogenchloride; sodium hydroxide 1.) H2O-dioxan, 25 deg C, 28 h, 2.) -5 deg C; Yield given. Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 28, # 52 p. 6535-6538
反应条件
1: 85 percent / 2-methyl-2-propanol; 5 percent NaH2PO4; 1M KMnO4 2: 80 percent / 85 percent AcOH / 0.67 h / 70 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 14, # 5 p. 549 - 554
反应条件
2: 1.) O3, Me2S, 2.) PCC / 1.) 3:1:3 CH2Cl2-MeOH-pentane, -78 deg C, 2.) CH2Cl2, 0 deg C, 8 h 3: 1.) 1.5 mol eq NaOH, 2.) HCl / 1.) H2O-dioxan, 25 deg C, 28 h, 2.) -5 deg C View Scheme
参考文献
Tetrahedron Letters, , vol. 28, # 52 p. 6535-6538
反应条件
1: 1.) O3, Me2S, 2.) PCC / 1.) 3:1:3 CH2Cl2-MeOH-pentane, -78 deg C, 2.) CH2Cl2, 0 deg C, 8 h 2: 1.) 1.5 mol eq NaOH, 2.) HCl / 1.) H2O-dioxan, 25 deg C, 28 h, 2.) -5 deg C View Scheme
参考文献
Tetrahedron Letters, , vol. 28, # 52 p. 6535-6538
参考文献
Justus Liebigs Annalen der Chemie, , p. 2245 - 2250
反应条件
multistep reaction, various reaction conditions; Product distribution;
参考文献
Synthesis, , # 12 p. 951 - 953
