1: 2-(6-methylpyridin-2-yl)malonic acid diethyl ester With potassium hydroxide; ethanol 1 h; Heating / reflux; 2: With hydrogenchloride; water T=0°C; 3: diazomethyl-trimethyl-silane With methanol in hexane 5 h;

1: 2,6-dimethylpyridine With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in tetrahydrofuran T=-78°C; Inert atmosphere; 2: carbonic acid dimethyl ester in tetrahydrofuran T=-78 - 20°C; Inert atmosphere;