boron tribromide in dichloromethane
T=-78 - 20°C; 6.75 h;
参考文献
Qi, Longwu; Yamamoto, Noboru; Meijler, Michael M.; Altobell III, Laurence J.; Koob, George F.; Wirsching, Peter; Janda, Kim D.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 23 p. 7389 - 7399
1.1: Mg / tetrahydrofuran / 1 h / Heating
1.2: 93 percent / tetrahydrofuran / -78 - 20 °C
2.1: TMSCl; NaI / acetonitrile; hexane; diethyl ether / 24 h / 20 °C
3.1: 1.236 g / BBr3 / CH2Cl2 / 36 h / 20 °C
View Scheme
参考文献
Qi, Longwu; Yamamoto, Noboru; Meijler, Michael M.; Altobell III, Laurence J.; Koob, George F.; Wirsching, Peter; Janda, Kim D.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 23 p. 7389 - 7399
1: TMSCl; NaI / acetonitrile; hexane; diethyl ether / 24 h / 20 °C
2: 1.236 g / BBr3 / CH2Cl2 / 36 h / 20 °C
View Scheme
参考文献
Qi, Longwu; Yamamoto, Noboru; Meijler, Michael M.; Altobell III, Laurence J.; Koob, George F.; Wirsching, Peter; Janda, Kim D.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 23 p. 7389 - 7399
1: 86 percent / PPh3; CBr4 / CH2Cl2 / 14 h / 20 °C
2: 98 percent / BBr3 / CH2Cl2 / 6.75 h / -78 - 20 °C
View Scheme
参考文献
Qi, Longwu; Yamamoto, Noboru; Meijler, Michael M.; Altobell III, Laurence J.; Koob, George F.; Wirsching, Peter; Janda, Kim D.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 23 p. 7389 - 7399
1: 99 percent / LiAlH4 / tetrahydrofuran / 2.67 h
2: 86 percent / PPh3; CBr4 / CH2Cl2 / 14 h / 20 °C
3: 98 percent / BBr3 / CH2Cl2 / 6.75 h / -78 - 20 °C
View Scheme
参考文献
Qi, Longwu; Yamamoto, Noboru; Meijler, Michael M.; Altobell III, Laurence J.; Koob, George F.; Wirsching, Peter; Janda, Kim D.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 23 p. 7389 - 7399
