N-(叔丁氧基羰基)-L-缬氨酸甲酯合成路线 （共 63 条）
反应条件
1.1: KHMDS / tetrahydrofuran / 0.67 h / -78 °C 1.2: 80 percent / trisyl azide; KOAc; AcOH / tetrahydrofuran / -78 - 20 °C 2.1: 90 percent / aq. LiOH / tetrahydrofuran / 0.5 h / 0 °C 3.1: SnCl2 / dioxane; H2O / 7 h / 0 - 20 °C 4.1: aq. NaOH / 1 h / 20 °C 5.1: 95 percent / diethyl ether 6.1: t-BuOOH; pyridine / CCl4 / 13 h / 20 °C 6.2: 93 percent / Et2NH / CCl4 / 4 h / 50 °C 7.1: 71 percent / H2 / Pd/C / ethyl acetate / 3 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 64, # 20 p. 7670 - 7674
反应条件
1.1: 90 percent / aq. LiOH / tetrahydrofuran / 0.5 h / 0 °C 2.1: SnCl2 / dioxane; H2O / 7 h / 0 - 20 °C 3.1: aq. NaOH / 1 h / 20 °C 4.1: 95 percent / diethyl ether 5.1: t-BuOOH; pyridine / CCl4 / 13 h / 20 °C 5.2: 93 percent / Et2NH / CCl4 / 4 h / 50 °C 6.1: 71 percent / H2 / Pd/C / ethyl acetate / 3 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 64, # 20 p. 7670 - 7674
反应条件
potassium hydrogencarbonate in N,N-dimethyl-formamide 5 h; Ambient temperature;
参考文献
Journal of Organic Chemistry, , vol. 52, # 7 p. 1252 - 1255
反应条件
in methanol; hexane Ambient temperature;
参考文献
Journal of Organic Chemistry, , vol. 61, # 24 p. 8402 - 8406
反应条件
potassium hydroxide; dipyridinium dichromate in methanol; N,N-dimethyl-formamide
参考文献
Organic letters, , vol. 3, # 6 p. 897 - 899
反应条件
in acetonitrile T=20°C;
参考文献
Tetrahedron Letters, , vol. 42, # 44 p. 7775 - 7777
Organic and Biomolecular Chemistry, , vol. 1, # 9 p. 1480 - 1485
反应条件
1: Et3N; DMAP / CH2Cl2 / 2 h / 20 °C 2: KMnO4; KOH / 2-methyl-propan-2-ol; H2O / 20 °C View Scheme
参考文献
Organic letters, , vol. 3, # 6 p. 897 - 899
反应条件
1: methanol; 2-aminoisovaleric acid With thionyl chloride Heating; 2: di-tert-butyl dicarbonate With sodium hydrogencarbonate in 1,4-dioxane; water T=20°C; Further stages.;
参考文献
Journal of Organic Chemistry, , vol. 73, # 13 p. 5180 - 5182
反应条件
triethylamine in dichloromethane T=0 - 20°C; Inert atmosphere;
参考文献
European Journal of Organic Chemistry, , vol. 2014, # 6 p. 1253 - 1265
反应条件
1: (2R,5S)-2-(3-tert-Butoxy-benzyl)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazine With hydrogenchloride 2: di-tert-butyl dicarbonate in dichloromethane T=20°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 24 p. 2759 - 2763
