N-(叔丁氧基羰基)-L-缬氨酸甲酯合成路线 （共 63 条）
反应条件
hydrogenchloride in 1,4-dioxane 0.5 h; Inert atmosphere;
参考文献
Kolundzic, Filip; Noshi, Mohammad N.; Tjandra, Meiliana; Movassaghi, Mohammad; Miller, Scott J.
Journal of the American Chemical Society, 2011 , vol. 133, # 23 p. 9104 - 9111
反应条件
in tetrahydrofuran Inert atmosphere;
参考文献
Podhajsky, Susanne M.; Iwai, Yasumasa; Cook-Sneathen, Amanda; Sigman, Matthew S.
Tetrahedron, 2011 , vol. 67, # 24 p. 4435 - 4441
反应条件
in tetrahydrofuran; diethyl ether T=20°C; 20 h;
参考文献
Gibson, Susan E.; Mainolfi, Nello; Kalindjian, S. Barret; Wright, Paul T.; White, Andrew J. P.
Chemistry - A European Journal, 2005 , vol. 11, # 1 p. 69 - 80
反应条件
in tetrahydrofuran 1.) 0 deg C, 2.) r.t., 20 h;
参考文献
Bull, Steven D.; Davies, Stephen G.; Jones, Simon; Polywka, Mario E. C.; Shyam Prasad; Sanganee, Hitesh J.
Synlett, 1998 , # 5 p. 519 - 521
反应条件
lithium hydroxide hydrate in methanol 8 h;
参考文献
Ghosh, Kumaresh; Majumdar, Anupam
Tetrahedron Letters, 2013 , vol. 54, # 42 p. 5686 - 5689
反应条件
1: 76 percent / tetrahydrofuran; diethyl ether / 20 h / 20 °C 2: 98 percent / HCl / ethyl acetate / 16 h / 20 °C View Scheme
参考文献
Gibson, Susan E.; Mainolfi, Nello; Kalindjian, S. Barret; Wright, Paul T.; White, Andrew J. P.
Chemistry - A European Journal, 2005 , vol. 11, # 1 p. 69 - 80
反应条件
1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere 2: hydrogenchloride; water / 1,4-dioxane / Inert atmosphere 3: triethylamine / 1,4-dioxane / 2 h / 0 °C / Inert atmosphere 4: methanesulfonic acid / dichloromethane / 0 - 20 °C / Inert atmosphere 5: potassium hydride / toluene / 20 - 120 °C / Inert atmosphere View Scheme
参考文献
Belanger, Etienne; Pouliot, Marie-France; Courtemanche, Marc-Andre; Paquin, Jean-Francois
Journal of Organic Chemistry, 2012 , vol. 77, # 1 p. 317 - 331
反应条件
1.1: DIBAL-H / toluene / 0.5 h / -78 °C
1.2: 93 percent / toluene; methanol / 12 h / -78 °C
2.1: 83 percent / 10 percent aq. NaOH / methanol / 18 h / 20 °C
3.1: 95 percent / H2 / 10 percent Pd/C / ethyl acetate / 3 h / 2327.17 Torr
View Scheme
参考文献
Yang, Hua; Jurkauskas, Valdas; Mackintosh, Nicole; Mogren, Tobias; Stephenson, Corey R. J.; Foster, Katherine; Brown, William; Roberts, Edward
Canadian Journal of Chemistry, 2000 , vol. 78, # 6 p. 800 - 808
反应条件
1: 87 percent / tetrahydrofuran; diethyl ether / 36 h / Ambient temperature
2: 71 percent / t-BuOK / tetrahydrofuran / 0.5 h / 0 °C
View Scheme
参考文献
Adams, Harry; Collins, Rebecca C.; Jones, Simon; Warner, Christopher J. A.
Organic Letters, 2011 , vol. 13, # 24 p. 6576 - 6579
参考文献
Coyle,S. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1979 , p. 1459 - 1463
