反应条件
1: N-methylmorpholine / CH2Cl2 / 0.25 h / 0 °C 2: N-methylmorpholine / CH2Cl2; dimethylformamide / 1.) 0 deg C, 1 h, 2.) to r. t., 1 h 3: HCl / methanol / 2 h 4: N-methylmorpholine, 2,6-lutidine / CH2Cl2; dimethylformamide / 1.) 0 deg C, 1 h, 2.) r. t., 1 h 5: 86 percent / HCl / methanol / 0.5 h / 35 °C 6: N-methylmorpholine, 2,6-lutidine / CH2Cl2; dimethylformamide / 1.) 0 deg C, 1 h, 2.) r. t., 1 h 7: HCl / methanol / 0.5 h / 35 °C 8: N-methylmorpholine, 2,6-luditine / CH2Cl2; dimethylformamide / 1.) 0 deg C, 1 h, 2.) r. t., 1 h 9: 91 percent / aq. NaOH / dimethylformamide / 6 h 10: 40 percent / aq. HCl / dioxane / 6 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 5 p. 551 - 556
