(6-甲氧基吡啶-3-基)甲醇合成路线 （共 13 条）
反应条件
sodium bis(2-methoxyethoxy)aluminium dihydride in tert-butyl methyl ether; toluene T=0°C; 1.63333 h;
参考文献
Eisai Co., Ltd.
Patent: US2006/235225 A1, 2006 ;
Location in patent: Page/Page column 3 ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 2: With water; ethyl acetate in toluene
参考文献
JANSSEN PHARMACEUTICA N.V.; ADDEX PHARMACEUTICALS S.A.
Patent: WO2006/30032 A1, 2006 ;
Location in patent: Page/Page column 104-105 ;
WO 2006/030032 A1
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
参考文献
Kozikowski; Xia; Reddy; Tuckmantel; Hanin; Tang
Journal of Organic Chemistry, 1991 , vol. 56, # 15 p. 4636 - 4645
反应条件
concentrated aqueous hydrochloric acid; sodium methylate in methanol; water; ethyl acetate
反应条件
1: 65 percent / Ag2CO3 2: 92 percent / LiAlH4 / tetrahydrofuran View Scheme
参考文献
Journal of Organic Chemistry, , vol. 56, # 15 p. 4636 - 4645
反应条件
1: 58 percent / H2SO4 / 12 h / 65 °C 2: 68 percent / LiAlH4 / diethyl ether / 1 h / 30 °C View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 50, # 5-6 p. 613 - 615
反应条件
manganese(IV) oxide in chloroform 0.0833333 h; Ambient temperature;
参考文献
Yamano, Kimiaki; Shirahama, Haruhisa
Tetrahedron, 1992 , vol. 48, # 8 p. 1457 - 1464
反应条件
nitrogen; sodium carbonate in water; toluene
参考文献
Bayer Aktiengesellschaft
Patent: US4990622 A1, 1991 ;
反应条件
1: 6-methoxy-3-hydroxymethyl pyridine With thionyl chloride in chloroform 2 h; Heating / reflux; 2: potassium cyanide in DMF (N,N-dimethyl-formamide) T=20°C;
参考文献
NOVO NORDISK A/S
Patent: WO2004/111031 A1, 2004 ;
Location in patent: Page 48 ;
WO 2004/111031 A1
反应条件
1: thionyl chloride / dichloromethane / 2 h / 0 - 20 °C 2: dimethyl sulfoxide / 18 h / 20 °C View Scheme
参考文献
Slowinski, Franck; Ben Ayad, Omar; Vache, Julien; Saady, Mourad; Leclerc, Odile; Lochead, Alistair
Journal of Organic Chemistry, 2011 , vol. 76, # 20 p. 8336 - 8346
