2,6-二氯-3-甲基吡啶合成路线 （共 13 条）
反应条件
n-butyllithium 1) THF, -80 deg C, 30 min, 2) 30 min; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Journal of Organic Chemistry, , vol. 56, # 15 p. 4793 - 4796
反应条件
triethylamine in dichloromethane; chlorobenzene
参考文献
Bayer Aktiengesellschaft
Patent: US5334724 A1, 1994 ;
反应条件
in toluene T=110°C; Cycloaddition; Hetero Diels-Alder reaction; 5 h;
参考文献
De Borggraeve, Wim; Rombouts, Frederik; Van Der Eycken, Erik; Hoornaert, Georges J.
Synlett, 2000 , # 5 p. 713 - 715
反应条件
triethylamine; trichlorophosphate in dichloromethane T=-10 - 20°C; 3.58333 h; Heating / reflux; Product distribution / selectivity;
参考文献
WO2005/103049 A1, ;
Page/Page column 72-73 ;
反应条件
triethylamine; trichlorophosphate in dichloromethane T=0 - 20°C; 4 h; Heating / reflux; Product distribution / selectivity;
参考文献
WO2005/103049 A1, ;
Page/Page column 71-72 ;
反应条件
1: With triethylamine; trichlorophosphate in dichloromethane T=0 - 20°C; 5 h; Inert atmosphere; 2: With ammonium chloride; zinc in water T=120°C; Microwave irradiationSealed tubeInert atmosphere;
参考文献
European Journal of Organic Chemistry, , # 35 p. 6940 - 6952
参考文献
Laeckmann, Didier; Rogister, Francoise; Dejardin, Jean-Victor; Prosperi-Meys, Christelle; Geczy, Joseph; Delarge, Jacques; Masereel, Bernard
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 6 p. 1793 - 1804
反应条件
1.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 18 h / 0 - 20 °C / |Inert atmosphere 2.1: triethylamine; trichlorophosphate / dichloromethane / 5 h / 0 - 20 °C / |Inert atmosphere 2.2: 120 °C / |Microwave irradiation; |Sealed tube; |Inert atmosphere View Scheme
参考文献
European Journal of Organic Chemistry, , # 35 p. 6940 - 6952
反应条件
1: 3-chloro-benzenecarboperoxoic acid / chloroform / 18 h / 0 - 20 °C / |Inert atmosphere 2: triethylamine; trichlorophosphate / dichloromethane / 5 h / 0 - 20 °C / |Inert atmosphere View Scheme
参考文献
European Journal of Organic Chemistry, , # 35 p. 6940 - 6952
反应条件
1: 65 percent / conc. H2SO4; AcOH / 1 h / 130 °C 2: OCl5 / 2 h / 150 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 10, # 6 p. 1793 - 1804
