2,3,6-三氯-5-甲基吡啶合成路线 （共 6 条）
反应条件
1: With potassium permanganate in water T=100°C; 60 h; 2: With hydrogenchloride in water T=0°C; pH=1 - 2;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/82392 A1, 2006 ;
Location in patent: Page/Page column 109-110 ;
WO 2006/082392 A1
反应条件
1: With phosphorus pentachloride
T=150°C; 2 h;
2: With water
T=0°C;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/82392 A1, 2006 ;
Location in patent: Page/Page column 110 ;
WO 2006/082392 A1
参考文献
Laeckmann, Didier; Rogister, Francoise; Dejardin, Jean-Victor; Prosperi-Meys, Christelle; Geczy, Joseph; Delarge, Jacques; Masereel, Bernard
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 6 p. 1793 - 1804
反应条件
1: acetyl chloride / Behandeln des erhaltenen Saeureanhydrids mit Ammoniak bei 120grad und Erhitzen des Reaktionsprodukts auf 200grad
2: phosphorus (V)-chloride
View Scheme
参考文献
Crouch; Lochte
Journal of the American Chemical Society, 1943 , vol. 65, p. 270
反应条件
1: 65 percent / conc. H2SO4; AcOH / 1 h / 130 °C
2: 45 percent / OCl5 / 2 h / 150 °C
View Scheme
参考文献
Laeckmann, Didier; Rogister, Francoise; Dejardin, Jean-Victor; Prosperi-Meys, Christelle; Geczy, Joseph; Delarge, Jacques; Masereel, Bernard
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 6 p. 1793 - 1804
参考文献
Crouch; Lochte
Journal of the American Chemical Society, 1943 , vol. 65, p. 270
