1-丙酮,1-(3-氟-4-甲氧基苯基)合成路线 （共 9 条）
反应条件
1: With oxalyl dichloride; dimethyl sulfoxide in dichloromethane T=-78°C; 2: With triethylamine in dichloromethane T=-78 - 20°C;
参考文献
EP2168960 A1, ;
Page/Page column 115 ;
反应条件
in tetrahydrofuran; diethyl ether T=0 - 20°C;
参考文献
CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; ZHU, Li; HU, Yuandong; YU, Rong; HU, Wei; ZHAO, Na; PENG, Yong; LUO, Hong; HAN, Yongxin
Patent: WO2013/97773 A1, 2013 ;
Location in patent: Paragraph 0167 ;
反应条件
1: in tetrahydrofuran T=-78 - 20°C; 2: With oxalyl dichloride; dimethyl sulfoxide in tetrahydrofuran; dichloromethane T=-78°C; Inert atmosphere; 3: With triethylamine in tetrahydrofuran; dichloromethane
参考文献
EP2168959 A1, ;
Page/Page column 165 ;
反应条件
1.1: tetrahydrofuran / 5 h / -78 - 20 °C / |Inert atmosphere 1.2: |Inert atmosphere 2.1: phosgene; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C 2.2: 2 h / -78 - 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 1 p. 375 - 381
反应条件
carbon disulfide; aluminium trichloride
参考文献
Journal of Organic Chemistry, , vol. 18, p. 910,914
反应条件
carbon disulfide; aluminium trichloride
参考文献
Journal of Organic Chemistry, , vol. 19, p. 1562,1565
反应条件
aluminium trichloride
参考文献
Helvetica Chimica Acta, , vol. 49, # 5 p. 1543 - 1551
反应条件
1: N,N-dimethyl-formamide / 120 °C 2: tetrahydrofuran; diethyl ether / 0 - 20 °C View Scheme
反应条件
water; hydrogen bromide
1 h; Reflux;
参考文献
CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; ZHU, Li; HU, Yuandong; YU, Rong; HU, Wei; ZHAO, Na; PENG, Yong; LUO, Hong; HAN, Yongxin
Patent: WO2013/97773 A1, 2013 ;
Location in patent: Paragraph 0168 ;
