反应条件
1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere; Cooling with ice 2.1: triethylamine / dichloromethane / 0 - 20 °C 3.1: n-butyllithium / diethyl ether; hexane / 1.5 h / -70 °C / Inert atmosphere; Cooling with acetone-dry ice 3.2: 4.5 h / -70 - 20 °C / Inert atmosphere; Cooling with acetone-dry ice View Scheme
参考文献
Keenan, Martine; Abbott, Michael J.; Alexander, Paul W.; Armstrong, Tanya; Best, Wayne M.; Berven, Bradley; Botero, Adriana; Chaplin, Jason H.; Charman, Susan A.; Chatelain, Eric; Von Geldern, Thomas W.; Kerfoot, Maria; Khong, Andrea; Nguyen, Tien; McManus, Joshua D.; Morizzi, Julia; Ryan, Eileen; Scandale, Ivan; Thompson, R. Andrew; Wang, Sen Z.; White, Karen L.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 9 p. 4189 - 4204