3,5-二苄氧基苯甲酸甲酯合成路线 （共 25 条）
反应条件
potassium carbonate in acetone T=20°C; 24 h;
参考文献
Denmark, Scott E.; Kobayashi, Tetsuya; Regens, Christopher S.
Tetrahedron, 2010 , vol. 66, # 26 p. 4745 - 4759
反应条件
potassium carbonate in N,N-dimethyl-formamide T=75°C; 8 h;
参考文献
Percec, Virgil; Peterca, Mihai; Sienkowska, Monika J.; Ilies, Marc A.; Aqad, Emad; Smidrkal, Jan; Heiney, Paul A.
Journal of the American Chemical Society, 2006 , vol. 128, # 10 p. 3324 - 3334
反应条件
potassium carbonate in acetone Benzylation; 5 h; Heating;
参考文献
Maekelae, Taru; Matikainen, Jorma; Waehaelae, Kristiina; Hase, Tapio
Tetrahedron, 2000 , vol. 56, # 13 p. 1873 - 1882
反应条件
1.1: 96 percent / H2SO4 / 5 h / Heating 2.1: K2CO3 / dimethylformamide / 2 h / 20 °C 2.2: 96 percent / dimethylformamide / 14.5 h / 20 °C View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 45, # 45 p. 7609 - 7611
反应条件
ammonium chloride in N,N-dimethyl-formamide
反应条件
1: 88 percent / LiAlH4 / diethyl ether / 4 h / 23 °C 2: 96 percent / pyridinium chlorochromate / CH2Cl2 / 3.5 h / 0 °C 3: 1.) NaH / 1.) THF, -5 deg C, 30 min, 2.) THF, RT 4: 69 percent / N,N-dimethylaniline, AlCl3 / CH2Cl2 / 0 °C View Scheme
参考文献
Thakkar, Kshitij; Geahlen, Robert L.; Cushman, Mark
Journal of Medicinal Chemistry, 1993 , vol. 36, # 20 p. 2950 - 2955
反应条件
1: 97 percent / LiAlH4 2: 84 percent / Et3N / CH2Cl2 / 0.33 h / 4 °C 3: 69 percent / benzyltriethylammonium chloride / H2O; CHCl3 / 2 h / Heating 4: 92 percent / aq. Ba(OH)2 / dioxane / 15 h / 115 °C View Scheme
参考文献
Meltzer, Peter C.; Dalzell, Haldean C.; Razdan, Raj K.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 2825 - 2829
反应条件
1: 90 percent / 10percent aq. NaOH / acetone / 2 h / Heating 2: 65 percent / SOCl2 / benzene / 5 h / Heating 3: 77 percent / (Et)3N / CH2Cl2 / 1.) 0 deg C, 2 h, 2.) RT, overnight 4: 96 percent / 47percent HBr / methanol; CHCl3 / 0.17 h / -10 °C View Scheme
参考文献
Szirmai; Odqvist; Halldin
Journal of Labelled Compounds and Radiopharmaceuticals, 1996 , vol. 38, # 4 p. 309 - 324
反应条件
1: 98 percent / LiAlH4 / tetrahydrofuran / 6.5 h / 0 - 20 °C 2: 88 percent / carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 1 h / 20 °C 3: 85 percent / potassium iodide; potassium carbonate; [18]crown-6 / acetone / 10 h / Heating 4: 94 percent / LiAlH / tetrahydrofuran / 0 - 20 °C View Scheme
参考文献
Chemistry - A European Journal, , vol. 13, # 12 p. 3346 - 3353
反应条件
1: 98 percent / LiAlH4 / tetrahydrofuran / 6.5 h / 0 - 20 °C 2: 88 percent / carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 1 h / 20 °C 3: 85 percent / potassium iodide; potassium carbonate; [18]crown-6 / acetone / 10 h / Heating 4: 94 percent / LiAlH / tetrahydrofuran / 0 - 20 °C 5: 83 percent / carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 20 °C View Scheme
参考文献
Freeman; Chrisstoffels; Frechet
Journal of Organic Chemistry, 2000 , vol. 65, # 22 p. 7612 - 7617
