3,5-二苄氧基苯甲酸甲酯合成路线 （共 25 条）
反应条件
1: 88 percent / LiAlH4 / diethyl ether / 4 h / 23 °C
2: 96 percent / pyridinium chlorochromate / CH2Cl2 / 3.5 h / 0 °C
3: 1.) NaH / 1.) THF, -5 deg C, 30 min, 2.) THF, RT
View Scheme
参考文献
Thakkar, Kshitij; Geahlen, Robert L.; Cushman, Mark
Journal of Medicinal Chemistry, 1993 , vol. 36, # 20 p. 2950 - 2955
反应条件
1: 91 percent / LiAlH4
2: 90 percent / C5H5*CrO3*HCl / CH2Cl2 / 8 h / 0 °C
3: 92 percent / benzene / 24 h / 25 °C
4: 77 percent / LiAlH4 / tetrahydrofuran / 2 h / 0 °C
5: 80 percent / H2 / 10 percent Pd/C / ethanol; ethyl acetate / 20 °C
View Scheme
参考文献
Cao, Xiaoping; Wang, Feng; Guo, Shu
Synthetic Communications, 2002 , vol. 32, # 20 p. 3149 - 3158
反应条件
1: 98 percent / LiAlH4 / diethyl ether
2: 84 percent / NEt3 / CH2Cl2
3: 69 percent / BzNEt3Cl / CHCl3; H2O
4: 92 percent / Ba(OH)2 / dioxane; H2O
5: diethyl ether
6: 99 percent / 60percent HClO4 / H2O; acetic acid
7: 97 percent / H2 / Pd/C (5percent) / ethyl acetate; ethanol
8: CH3ONa / methanol
9: NaBH4 / methanol
View Scheme
参考文献
Ichinose, Koji; Ebizuka, Yutaka; Sankawa, Ushio
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 10 p. 2873 - 2875
反应条件
1: sodium hydroxide / ethanol
2: thionyl chloride / toluene
3: 1,3-bis-(1-adamantyl)imidazolinium tetrafluoroborate; palladium diacetate; n-ethyl morpholine / para-xylene / 3 h / 115 - 120 °C / |Inert atmosphere
4: dimethylsulfide; boron trifluoride diethyl etherate / dichloromethane / 20 h / |Inert atmosphere
View Scheme
参考文献
Acerson, Mark J.; Fabick, Kimberly M.; Wong, Yong; Blake, Crystal; Lephart, Edwin D.; Andrus, Merritt B.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 10 p. 2941 - 2944
反应条件
1: 90 percent / 10percent aq. NaOH / acetone / 2 h / Heating
2: 65 percent / SOCl2 / benzene / 5 h / Heating
3: 77 percent / (Et)3N / CH2Cl2 / 1.) 0 deg C, 2 h, 2.) RT, overnight
View Scheme
参考文献
Szirmai; Odqvist; Halldin
Journal of Labelled Compounds and Radiopharmaceuticals, 1996 , vol. 38, # 4 p. 309 - 324
