3-氟-N-羟基苯甲醛肟氯化物合成路线 （共 4 条）
反应条件
1: triethylamine / diethyl ether / 0 - 20 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 20 °C View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; DOTT, Pascal; HANLON, Steven Paul; HILDBRAND, Stefan; IDING, Hans; THOMAS, Andrew; WALDMEIER, Pius
Patent: WO2013/57123 A1, 2013 ;
反应条件
N-chloro-succinimide in N,N-dimethyl-formamide
T=20 - 35°C; 2 h;
参考文献
F. HOFFMANN-LA ROCHE AG; DOTT, Pascal; HANLON, Steven Paul; HILDBRAND, Stefan; IDING, Hans; THOMAS, Andrew; WALDMEIER, Pius
Patent: WO2013/57123 A1, 2013 ;
Location in patent: Page/Page column 30 ;
反应条件
1: aq. NH2OH*HCl; AcONa / ethanol / 12 h
2: N-chlorosuccinimide; pyridine / CHCl3; tetrahydrofuran / 2 h
View Scheme
参考文献
Lam, Patrick Y. S.; Adams, Jessica J.; Clark, Charles G.; Calhoun, W. Jason; Luettgen, Joseph M.; Knabb, Robert M.; Wexler, Ruth R.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 10 p. 1795 - 1799
反应条件
triethylamine in diethyl ether
T=0 - 20°C;
参考文献
F. HOFFMANN-LA ROCHE AG; DOTT, Pascal; HANLON, Steven Paul; HILDBRAND, Stefan; IDING, Hans; THOMAS, Andrew; WALDMEIER, Pius
Patent: WO2013/57123 A1, 2013 ;
Location in patent: Page/Page column 31 ;
