(2R,3S,4R,5R)-2-(氨基甲基)-5-(6-(苄基氨基)-1H-嘌呤-9(6H)-基)四氢呋喃-3,4-二醇合成路线 （共 5 条）
反应条件
1: in methanol
T=20°C; 0.5 h;
2: With sodium tris(acetoxy)borohydride; potassium carbonate
pH=8; 2 h;
参考文献
EPIZYME, INC.; CHESWORTH, Richard; KUNTZ, Kevin, Wayne; OLHAVA, Edward, James; PATANE, Michael, A.
Patent: WO2012/82436 A2, 2012 ;
Location in patent: Page/Page column 195 ;
WO 2012/082436 A2
反应条件
1.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 20 °C
2.1: hydrazine hydrate / ethanol / 3 h / 20 °C / Reflux
3.1: methanol / 0.5 h / 20 °C
3.2: 2 h
3.3: pH 8
View Scheme
参考文献
EPIZYME, INC.; CHESWORTH, Richard; KUNTZ, Kevin, Wayne; OLHAVA, Edward, James; PATANE, Michael, A.
Patent: WO2012/82436 A2, 2012 ;
WO 2012/082436 A2
反应条件
1.1: hydrazine hydrate / ethanol / 3 h / 20 °C / Reflux
2.1: methanol / 0.5 h / 20 °C
2.2: 2 h
2.3: pH 8
View Scheme
参考文献
EPIZYME, INC.; CHESWORTH, Richard; KUNTZ, Kevin, Wayne; OLHAVA, Edward, James; PATANE, Michael, A.
Patent: WO2012/82436 A2, 2012 ;
WO 2012/082436 A2
反应条件
1: methanol / 3 h / |Molecular sieve; |Inert atmosphere
2: sodium tetrahydroborate / methanol / 0.5 h
View Scheme
参考文献
Moukha-Chafiq, Omar; Reynolds, Robert C.
ACS Combinatorial Science, 2013 , vol. 15, # 3 p. 147 - 152
反应条件
1.1: toluene-4-sulfonic acid / water
1.2: 1 h
1.3: pH 8
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 20 °C
3.1: hydrazine hydrate / ethanol / 3 h / 20 °C / Reflux
4.1: methanol / 0.5 h / 20 °C
4.2: 2 h
4.3: pH 8
View Scheme
参考文献
EPIZYME, INC.; CHESWORTH, Richard; KUNTZ, Kevin, Wayne; OLHAVA, Edward, James; PATANE, Michael, A.
Patent: WO2012/82436 A2, 2012 ;
WO 2012/082436 A2
