2-(叔丁氧羰基氧亚氨基)-2-苯乙腈合成路线 （共 188 条）
参考文献
Zhang, Lin-hua; Ma, Philip
Tetrahedron Letters, 1994 , vol. 35, # 32 p. 5765 - 5768
反应条件
1: 2-(tert-butoxycarbonyloxyimino)-2-phenylacetonitrile; D,L-piperazine-2-carboxylic acid dihydrochloride With sodium hydroxide in 1,4-dioxane; water T=20°C; pH=11; 2: N-(benzyloxycarbonyloxy)-succinimide in 1,4-dioxane; water T=0 - 20°C; pH=10; 3: With hydrogenchloride in diethyl ether; water pH=1;
参考文献
ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A.; BRANCA, Danila; FERRIGNO, Federica; HERNANDO, Jose, Ignacio, Martin; JONES, Philip; KINZEL, Olaf; MALANCONA, Savina; MURAGLIA, Ester; PALUMBI, Maria, Cecilia; PESCATORE, Giovanna; SCARPELLI, Rita
Patent: WO2010/23480 A1, 2010 ;
Location in patent: Page/Page column 43-44 ;
反应条件
sodium hydroxide in 1,4-dioxane; water
参考文献
Warner-Lambert
Patent: US6251919 B1, 2001 ;
US 6251919 B1
反应条件
triethylamine in N,N-dimethyl-formamide T=55°C; 3 h;
参考文献
Seto, Christopher T.; Mathias, John P.; Whitesides, George M.
Journal of the American Chemical Society, 1993 , vol. 115, # 4 p. 1321 - 1329
反应条件
sodium hydroxide in 1,4-dioxane; water T=20°C; pH=11; 2 h;
参考文献
PRESIDENT AND FELLOWS OF HARVARD COLLEGE; CHOREV, Michael; AKTAS, Bertal Huseyin; HALPERIN, Jose A.; WAGNER, Gerhard
Patent: WO2012/6068 A2, 2012 ;
Location in patent: Page/Page column 113-114 ;
反应条件
in methanol T=20°C; 20 h;
参考文献
Farmaco, , vol. 59, # 12 p. 987 - 992
反应条件
1: triethylamine / dioxane; H2O / 4 h / Ambient temperature 2: NaH / tetrahydrofuran / 24 h / Ambient temperature View Scheme
参考文献
Kajiyama, Shin-Ichiro; Irie, Kazuhiro; Kido, Takae; Koshimizu, Koichi; Hayashi, Hideo; Arai, Motoo
Tetrahedron, 1991 , vol. 47, # 29 p. 5453 - 5462
反应条件
triethylamine in 1,4-dioxane; water 18 h;
参考文献
Camphausen, Kevin; Sproull, Mary; Tantama, Steve; Venditto, Vincent; Sankineni, Sandeep; Scott, Tamalee; Brechbiel, Martin W.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 19 p. 5133 - 5140
反应条件
triethylamine in chloroform 15 h;
参考文献
Giardina, Dario; Gulini, Ugo; Massi, Maurizio; Piloni, Maria G.; Pompei, Pierluigi; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 6 p. 690 - 698
反应条件
triethylamine in 1,4-dioxane; water T=20°C; 24 h;
参考文献
Journal of Organic Chemistry, , vol. 66, # 11 p. 3709 - 3716
