2-(叔丁氧羰基氧亚氨基)-2-苯乙腈合成路线 （共 188 条）
反应条件
hydrogenchloride; sodium hydroxide; sodium borohydride; potassium carbonate; dimethyl sulfate; lithium chloride in tetrahydrofuran; 1,4-dioxane; dioxane - water; diethyl ether; ethanol; dichloromethane; acetone
参考文献
Merck and Co., Inc.
Patent: US6316444 B1, 2001 ;
US 6316444 B1
反应条件
triethylamine in chloroform 4 h; Ambient temperature;
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 5 p. 898 - 901
反应条件
1: triethylamine / dioxane; H2O / 4 h / Ambient temperature 2: NaH / tetrahydrofuran / 24 h / Ambient temperature View Scheme
参考文献
Kajiyama, Shin-Ichiro; Irie, Kazuhiro; Kido, Takae; Koshimizu, Koichi; Hayashi, Hideo; Arai, Motoo
Tetrahedron, 1991 , vol. 47, # 29 p. 5453 - 5462
反应条件
in methanol T=20°C; 20 h;
参考文献
Corelli, Federico; Botta, Maurizio; Lossani, Andrea; Pasquini, Serena; Spadari, Silvio; Focher, Federico
Farmaco, 2004 , vol. 59, # 12 p. 987 - 992
反应条件
1: triethylamine / dioxane; H2O / 4 h / Ambient temperature 2: NaH / tetrahydrofuran / 24 h / Ambient temperature View Scheme
参考文献
Kajiyama, Shin-Ichiro; Irie, Kazuhiro; Kido, Takae; Koshimizu, Koichi; Hayashi, Hideo; Arai, Motoo
Tetrahedron, 1991 , vol. 47, # 29 p. 5453 - 5462
反应条件
1: Et3N / dioxane; H2O / 20 h / Ambient temperature 2: 64 percent / thallium trinitrate trihydrate / 27 °C 3: 70 percent / H2, 10percent HCl / 10percent Pd/C / ethanol / 1 h / 60 °C View Scheme
参考文献
Mukai, Chisato; Kim, In Jong; Furu, Etsuko; Hanaoka, Miyoji
Tetrahedron, 1993 , vol. 49, # 37 p. 8323 - 8336
反应条件
triethylamine in 1,4-dioxane; methanol; hexane; water; benzene
参考文献
Franchini; Corbo; Lentini; Bruno; Scilimati; Tortorella; Camerino; De Luca
Journal of Medicinal Chemistry, 2000 , vol. 43, # 20 p. 3792 - 3798
反应条件
triethylamine in chloroform T=23°C; 15 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 24 p. 6017 - 6021
反应条件
hydrogenchloride in 1,4-dioxane T=0 - 20°C; 1.5 h;
参考文献
Journal of the American Chemical Society, , vol. 118, # 16 p. 3789 - 3800
反应条件
triethylamine in 1,4-dioxane; water Ambient temperature;
参考文献
Kajiyama, Shin-Ichiro; Irie, Kazuhiro; Kido, Takae; Koshimizu, Koichi; Hayashi, Hideo; Arai, Motoo
Tetrahedron, 1991 , vol. 47, # 29 p. 5453 - 5462
