2-(叔丁氧羰基氧亚氨基)-2-苯乙腈合成路线 （共 188 条）
反应条件
triethylamine in 1,4-dioxane; water 4 h; Ambient temperature;
参考文献
Kajiyama, Shin-Ichiro; Irie, Kazuhiro; Kido, Takae; Koshimizu, Koichi; Hayashi, Hideo; Arai, Motoo
Tetrahedron, 1991 , vol. 47, # 29 p. 5453 - 5462
反应条件
triethylamine in 1,4-dioxane; water 3 h;
参考文献
Platen, Martin; Steckhan, Eberhard
Liebigs Annalen der Chemie, 1984 , # 9 p. 1563 - 1576
反应条件
triethylamine in water; acetone
参考文献
Ho, Bin; Venkatarangan, Prabha M.; Cruse, Sharon F.; Hinko, Christine N.; Andersen, Peter H.; Crider, Albert M.; Adloo, Ahmad A.; Roane, David S.; Stables, James P.
European Journal of Medicinal Chemistry, 1998 , vol. 33, # 1 p. 23 - 31
反应条件
2,3-dihydroxybutanedioic acid; triethylamine 1.) EtOH, 2.) THF, H2O, RT, 40 h; Yield given. Multistep reaction;
参考文献
Nakatsuka, Masashi; Ragan, John A.; Sammakia, Tarek; Smith, David B.; Uehling, David E.; Schreiber, Stuart L.
Journal of the American Chemical Society, 1990 , vol. 112, # 14 p. 5583 - 5601
反应条件
1: 2-(tert-butoxycarbonyloxyimino)-2-phenylacetonitrile; S-(-)-piperazine-2-carboxylic acid dihydrochloride With sodium hydroxide in 1,4-dioxane; water T=20°C; pH=11; 2: N-(benzyloxycarbonyloxy)-succinimide in 1,4-dioxane; water T=0 - 20°C; pH=10; 3: With hydrogenchloride in diethyl ether; water pH=1;
参考文献
ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A.; BRANCA, Danila; FERRIGNO, Federica; HERNANDO, Jose, Ignacio, Martin; JONES, Philip; KINZEL, Olaf; MALANCONA, Savina; MURAGLIA, Ester; PALUMBI, Maria, Cecilia; PESCATORE, Giovanna; SCARPELLI, Rita
Patent: WO2010/23480 A1, 2010 ;
Location in patent: Page/Page column 41 ;
反应条件
1: 40percent NaOH / dioxane; H2O / 2.5 h 2: 40percent NaOH / dioxane; H2O / 14 h View Scheme
参考文献
Dorsey; Levin; McDaniel; Vacca; Guare; Darke; Zugay; Emini; Schleif; Quintero; Lin; Chen -; Holloway; Fitzgerald; Axel; Ostovic; Anderson; Huff
Journal of Medicinal Chemistry, 1994 , vol. 37, # 21 p. 3443 - 3451
反应条件
1: With triethylamine in 1,4-dioxane; water T=20°C; 3 h; 2: With citric acid in 1,4-dioxane; water pH=~ 2;
参考文献
WO2004/113290 A1, ;
Page/Page column 41-42 ;
WO 2004/113290 A1
反应条件
in tetrahydrofuran; chloroform
参考文献
Melchiorre; Bolognesi; Budriesi; Ghelardini; Chiarini; Minarini; Rosini; Tumiatti; Wade
Journal of Medicinal Chemistry, 2001 , vol. 44, # 24 p. 4035 - 4038
参考文献
Manetti, Dina; Mannelli, Lorenzo Di Cesare; Dei, Silvia; Guandalini, Luca; Martini, Elisabetta; Banchelli, Martina; Ghelardini, Carla
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 8 p. 2224 - 2229
反应条件
1: 2-methoxycarbonylmethylpiperazine dihyrochloride With potassium carbonate in water; ethyl acetate T=20°C; P=1551.49 Torr; 22 h; 2: 2-(tert-butoxycarbonyloxyimino)-2-phenylacetonitrile in water; ethyl acetate T=20°C; 3.08333 h; Cooling with ice;
参考文献
ABBOTT LABORATORIES
Patent: US2011/288069 A1, 2011 ;
Location in patent: Page/Page column 40 ;
