2-(叔丁氧羰基氧亚氨基)-2-苯乙腈合成路线

参考文献

Davey, David D.; Adler, Marc; Arnaiz, Damian; Eagen, Keith; Erickson, Shawn; Guilford, William; Kenrick, Margaret; Morrissey, Michael M.; Ohlmeyer, Mike; Pan, Gonghua; Paradkar, Vidyadhar M.; Parkinson, John; Polokoff, Mark; Saionz, Kurt; Santos, Cecile; Subramanyam, Babu; Vergona, Ron; Wei, Robert G.; Whitlow, Marc; Ye, Bin; Zhao, Zuchun; Devlin, James J.; Phillips, Gary
Journal of Medicinal Chemistry, 2007 , vol. 50, # 6 p. 1146 - 1157

58632-95-42-(叔丁氧羰基氧亚氨基)-2-苯乙腈+

169280-56-24-氨基-N-[(2R, 3S)-3-氨基-2-羟基-4-苯丁基]-N-异丁基苯磺酰胺

183004-94-6[(1S,2R)-1-苄基-2-羟基-3-[异丁基-[(4-氨基苯基)磺酰基]氨基] 丙基]氨基甲酸叔丁酯

参考文献

G. D. Searle and Co.
Patent: US6388132 B1, 2002 ;
Location in patent: Page column 84 ;

58632-95-42-(叔丁氧羰基氧亚氨基)-2-苯乙腈+

84477-72-52,2-二甲基哌嗪

259808-67-83,3-二甲基哌嗪-1-甲酸叔丁酯

参考文献

Elzein, Elfatih; Ibrahim, Prabha; Koltun, Dmitry O.; Rehder, Ken; Shenk, Kevin D.; Marquart, Timothy A.; Jiang, Bob; Li, Xiaofen; Natero, Reina; Li, Yuan; Nguyen, Marie; Kerwar, Suresh; Chu, Nancy; Soohoo, Daniel; Hao, Jia; Maydanik, Victoria Y.; Lustig, David A.; Zeng, Dewan; Leung, Kwan; Zablocki, Jeff A.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 24 p. 6017 - 6021

5934-29-2L-盐酸组氨酸一水物+

58632-95-42-(叔丁氧羰基氧亚氨基)-2-苯乙腈

17791-52-5N-Boc-L-组氨酸

参考文献

Chemical and Pharmaceutical Bulletin, , vol. 37, # 11 p. 3112 - 3113

58632-95-42-(叔丁氧羰基氧亚氨基)-2-苯乙腈+

71-00-1L-组氨酸

17791-52-5N-Boc-L-组氨酸

参考文献

Bulletin des Societes Chimiques Belges, , vol. 99, # 10 p. 779 - 782

58632-95-42-(叔丁氧羰基氧亚氨基)-2-苯乙腈+

498-63-5吡咯烷-2-甲醇

170491-63-12-羟甲基吡咯烷-1-羧酸丁酯

参考文献

Hofmann, Thomas; Schieberle, Peter
Journal of Agricultural and Food Chemistry, 1998 , vol. 46, # 6 p. 2270 - 2277

2762-32-5+

13139-17-8+

58632-95-42-(叔丁氧羰基氧亚氨基)-2-苯乙腈

149057-19-2

参考文献

BIKAM PHARMACEUTICALS, INC.; GARVEY, David, S.; LAROSA, Gregory, J.; GREENWOOD, Jeremy, Robert; BREWER, Mark, L.; QUACH, Tan; COTE, Jamie, B.; BERMAN, Judd
Patent: WO2010/147653 A1, 2010 ;
Location in patent: Page/Page column 117-118 ;

2149-70-4+

58632-95-42-(叔丁氧羰基氧亚氨基)-2-苯乙腈

2188-18-3

参考文献

Itoh,M. et al.
Tetrahedron Letters, 1975 , p. 4393 - 4394

58632-95-42-(叔丁氧羰基氧亚氨基)-2-苯乙腈+

1436-59-5

184954-75-4

参考文献

Cherney, Robert J.; Mo, Ruowei; Meyer, Dayton T.; Nelson, David J.; Lo, Yvonne C.; Yang, Gengjie; Scherle, Peggy A.; Mandlekar, Sandhya; Wasserman, Zelda R.; Jezak, Heather; Solomon, Kimberly A.; Tebben, Andrew J.; Carter, Percy H.; Decicco, Carl P.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 4 p. 721 - 724

58632-95-42-(叔丁氧羰基氧亚氨基)-2-苯乙腈

120005-55-2

参考文献

Nimkar; Menaldino; Merrill; Liotta
Tetrahedron Letters, 1988 , vol. 29, # 25 p. 3037 - 3040