2,2-二甲基-1-[4-(三氟甲基)苯基]-1-丙酮合成路线 （共 7 条）
反应条件
1: 1-trifluoromethyl-4-bromobenzene With magnesium in tetrahydrofuran
T=20°C; 1 h;
2: pivalaldehyde in tetrahydrofuran
T=0 - 20°C; 2 h;
3: With 1,3-Diiodo-5,5-dimethyl-2,4-imidazolidinedione; potassium carbonate in tetrahydrofuran; tert-butyl alcohol
20 h; RefluxDarkness;
参考文献
Dohi, Souya; Moriyama, Katsuhiko; Togo, Hideo
Tetrahedron, 2012 , vol. 68, # 32 p. 6557 - 6564
反应条件
C10H16NO5; potassium carbonate; bis-[(trifluoroacetoxy)iodo]benzene in dichloromethane
T=0°C; Resolution of racemate;
参考文献
Hamada, Shohei; Wada, Yoshiyuki; Sasamori, Takahiro; Tokitoh, Norihiro; Furura, Takumi; Kawabata, Takeo
Tetrahedron Letters, 2014 , vol. 55, # 11 p. 1943 - 1945
反应条件
copper(l) iodide; lithium tert-butylate in tetrahydrofuran; pentane
T=-78°C; 0.5 h; Inert atmosphere;
参考文献
Fujihara, Tetsuaki; Semba, Kazuhiko; Terao, Jun; Tsuji, Yasushi
Angewandte Chemie - International Edition, 2010 , vol. 49, # 8 p. 1472 - 1476
反应条件
AZADO; bis-[(trifluoroacetoxy)iodo]benzene in dichloromethane
T=20°C; 4 h;
参考文献
Hamada, Shohei; Furuta, Takumi; Wada, Yoshiyuki; Kawabata, Takeo
Angewandte Chemie - International Edition, 2013 , vol. 52, # 31 p. 8093 - 8097
Angew. Chem., 2013 , vol. 125, # 31 p. 8251 - 8255,5
反应条件
C10H16NO5; potassium carbonate; bis-[(trifluoroacetoxy)iodo]benzene in dichloromethane
T=20°C;
参考文献
Hamada, Shohei; Furuta, Takumi; Wada, Yoshiyuki; Kawabata, Takeo
Angewandte Chemie - International Edition, 2013 , vol. 52, # 31 p. 8093 - 8097
Angew. Chem., 2013 , vol. 125, # 31 p. 8251 - 8255,5
反应条件
[Bu4N]4W10O32; oxygen in acetonitrile
T=5 - 10°C; 0.333333 h; Photolysis; Product distribution; Further Variations:SolventsReagents;
参考文献
Lykakis, Ioannis N.; Tanielian, Charles; Orfanopoulos, Michael
Organic Letters, 2003 , vol. 5, # 16 p. 2875 - 2878
反应条件
magnesium
1.) ether, 2.) ether, -15 deg C; Multistep reaction;
参考文献
Tsuji; Fujio; Tsuno
Bulletin of the Chemical Society of Japan, 1990 , vol. 63, # 3 p. 856 - 866
