1: With trifluoroacetic acid in dichloromethane
T=20°C; 0.75 h;
2: With hydrogenchloride; water
T=60°C; 0.333333 h;
3: With sodium hydroxide in water
pH=14;
参考文献
AMGEN INC.
Patent: WO2005/70932 A2, 2005 ;
Location in patent: Page/Page column 31 ;
WO 2005/070932 A2
