甲基(R)-3-羟基-3-苯基丙酸合成路线 （共 33 条）
反应条件
hydrogen; [NH2Me2][{RuCl[(R)-segphos]}2(μ-Cl)3] in methanol T=80°C; P=22067.3 Torr; 6 h;
参考文献
Saito, Takao; Yokozawa, Tohru; Ishizaki, Takero; Moroi, Takashi; Sayo, Noboru; Miura, Takashi; Kumobayashi, Hidenori
Advanced Synthesis and Catalysis, 2001 , vol. 343, # 3 p. 264 - 267
反应条件
lithium borohydride; N,N'-bis(benzoyl)-L-cystine; tert-butyl alcohol in tetrahydrofuran T=-78 - -30°C; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of the Chemical Society, Chemical Communications, , # 3 p. 138 - 139
反应条件
Burkholderia cepacia amano PS-IM lipase in toluene T=30°C; Resolution of racemateEnzymatic reaction; Reagent/catalystSolvent; enantioselective reaction;
参考文献
Tetrahedron Asymmetry, , vol. 24, # 15-16 p. 925 - 936
反应条件
aluminium amalgam T=0°C; Dehalogenation;
参考文献
Wang, Ying-Chuan; Yan, Tu-Hsin
Chemical Communications, 2000 , # 7 p. 545 - 546
参考文献
Justus Liebigs Annalen der Chemie, , vol. 626, p. 150,152
Tetrahedron Letters, , vol. 26, # 3 p. 351 - 354
反应条件
2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride in toluene Reduction; reflux;
参考文献
Corey; Choi, Soongyu
Tetrahedron Letters, 2000 , vol. 41, # 16 p. 2769 - 2772
反应条件
1: chiral Ti(IV) complex / diethyl ether / 4 h / -10 °C 2: Bu4NF / tetrahydrofuran View Scheme
参考文献
Journal of the American Chemical Society, , vol. 116, # 19 p. 8837 - 8838
反应条件
in methanol T=0°C; 0.5 h;
参考文献
Kishikawa, Keiki; Yamamoto, Makoto; Kohmoto, Shigeo; Yamada, Kazutoshi
Chemistry Letters, 1989 , p. 787 - 790
反应条件
1: 43 percent / H3BO3, H2 / Raney-Ni / methanol; H2O / 4 h 2: 1.) 0.1 N NaOH / 1.) water, rt; 2.) ether, 0 deg C, 15 min View Scheme
参考文献
Tetrahedron, , vol. 40, # 19 p. 3769 - 3776
反应条件
air; C14H21N; dimethyl zinc; triphenyl-phosphine oxide in tetrahydrofuran; diethyl ether; toluene T=0°C; Reformatsky reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Advanced Synthesis and Catalysis, , vol. 350, # 7-8 p. 975 - 978
