甲基(R)-3-羟基-3-苯基丙酸合成路线 （共 33 条）
反应条件
tetrachlorosilane; (R,R)-N,N'-bis(phosphoramide)-N,N'-Me2-1,5-pentanediamine in dichloromethane T=-78°C; 0.25 h; Title compound not separated from byproducts;
参考文献
Journal of the American Chemical Society, , vol. 127, # 11 p. 3774 - 3789
反应条件
potassium fluoride; 3-chloro-benzenecarboperoxoic acid in N,N-dimethyl-formamide 5 h; Ambient temperature; Yield given;
参考文献
Journal of Organic Chemistry, , vol. 61, # 14 p. 4542 - 4554
反应条件
1: 68 percent / (-)-sparteine, s-BuLi / tetrahydrofuran / -78 °C 2: 67 percent / Et3N, DMAP / CH2Cl2 / 7 h / Ambient temperature 3: 57 percent / methanol / 0.67 h 4: 105 mg / HBF4*Et2O / CH2Cl2 / 3 h / Ambient temperature 5: m-CPBA, KF / dimethylformamide / 5 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 14 p. 4542 - 4554
反应条件
1: 105 mg / HBF4*Et2O / CH2Cl2 / 3 h / Ambient temperature 2: m-CPBA, KF / dimethylformamide / 5 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 14 p. 4542 - 4554
反应条件
1: 57 percent / methanol / 0.67 h 2: 105 mg / HBF4*Et2O / CH2Cl2 / 3 h / Ambient temperature 3: m-CPBA, KF / dimethylformamide / 5 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 14 p. 4542 - 4554
反应条件
1: DCC; 4-(dimethylamino)pyridine / CH2Cl2 / 20 °C 2: Candida rugosa lipase; MgCl2 / H2O; diisopropyl ether / 24 h / 30 °C View Scheme
参考文献
Tetrahedron, , vol. 61, # 8 p. 2169 - 2186
反应条件
potassium carbonate 14 h; Ambient temperature;
参考文献
Cambie, Richard C.; Coddington, Jan M.; Milbank, Jared B. J.; Pausler, Maria G.; Rustenhoven, Job J.; et al.
Australian Journal of Chemistry, 1993 , vol. 46, # 5 p. 583 - 591
反应条件
trifluoroacetic acid; Eu(hfc)3 in chloroform-d1 T=-10°C; other temperature; Product distribution;
参考文献
Tetrahedron Letters, , vol. 24, # 33 p. 3451 - 3454
反应条件
1: 85 percent / KOH / methanol; H2O / 15 h / Heating 2: diethyl ether View Scheme
参考文献
Chemische Berichte, , vol. 119, # 7 p. 2191 - 2207
反应条件
(-)-N,N-dimethylaminoisoborneol; diethylzinc in tetrahydrofuran T=-20 - 0°C; Reformatsky reaction; 12 h; Product distribution; Further Variations:Reagents;
参考文献
Organic Letters, , vol. 8, # 6 p. 1125 - 1128
