N-[(1S,2S)-2-氨基环戊基]氨基甲酸叔丁酯合成路线 （共 13 条）
反应条件
1: With sodium azide in DMF (N,N-dimethyl-formamide) T=80°C; 12 h; 2: With hydrogen; 5-palladium/activated carbon in ethanol P=760.051 Torr; 24 h;
参考文献
WO2003/99276 A1, ;
Page 469 ;
WO 03/099276 A1
反应条件
Candida antarctica lipase T=10°C; Enzymatic reactionInert atmosphereResolution of racemate;
参考文献
EP2319825 A1, ;
Page/Page column 17-18 ;
反应条件
hydrogen; palladium on activated charcoal in methanol P=2844.31 Torr; 12 h;
参考文献
Journal of the American Chemical Society, , vol. 126, # 46 p. 15067 - 15073
反应条件
N,N'-dimethyl-barbituric acid; tetrakis(triphenylphosphine) palladium(0) in dichloromethane T=35°C; 7 h;
参考文献
Tetrahedron Asymmetry, , vol. 19, # 6 p. 751 - 755
反应条件
hydrogen; palladium on activated charcoal in methanol 5 h;
参考文献
Journal of Organic Chemistry, , vol. 72, # 4 p. 1309 - 1314
反应条件
sodium hydroxide; water in ethyl acetate
参考文献
WO2008/39367 A1, ;
Page/Page column 14-15 ;
反应条件
1.1: Et3N; ethyl chloroformate / tetrahydrofuran / 0.33 h / 0 °C 1.2: aq. NaN3 / tetrahydrofuran / 0.33 h / 0 °C 2.1: 2.15 g / benzene / 0.5 h / Heating 3.1: 89 percent / CuCl / dimethylformamide / 0.75 h / 20 °C 4.1: H2 / Pd/C / methanol / 12 h / 2844.31 Torr View Scheme
参考文献
Journal of the American Chemical Society, , vol. 126, # 46 p. 15067 - 15073
反应条件
1.1: Et3N; ethyl chloroformate / tetrahydrofuran / 0.33 h / 0 °C 1.2: aq. NaN3 / tetrahydrofuran / 0.33 h / 0 °C 2.1: 2.15 g / benzene / 0.5 h / Heating 3.1: 89 percent / CuCl / dimethylformamide / 0.75 h / 20 °C 4.1: H2 / Pd/C / methanol / 12 h / 2844.31 Torr View Scheme
参考文献
Journal of the American Chemical Society, , vol. 126, # 46 p. 15067 - 15073
反应条件
1: 89 percent / CuCl / dimethylformamide / 0.75 h / 20 °C 2: H2 / Pd/C / methanol / 12 h / 2844.31 Torr View Scheme
参考文献
Journal of the American Chemical Society, , vol. 126, # 46 p. 15067 - 15073
反应条件
1: With lead(IV) tetraacetate in methanol; dichloromethane T=0°C; 0.5 h; Inert atmosphere; 2: With hydroxylamine hydrochloride in methanol; dichloromethane T=0°C; 0.5 h; Inert atmosphere;
参考文献
Organic Letters, , vol. 12, # 22 p. 5128 - 5131
