5,5-二甲基-1,3-二恶烷-2-丙醛合成路线 （共 3 条）
反应条件
triethylamine in dichloromethane; dimethyl sulfoxide
参考文献
G. D. Searle and Co.
Patent: US5932598 A1, 1999 ;
反应条件
1: With toluene-4-sulfonic acid in toluene
T=110°C; 1 h; Inert atmosphere;
2: With diisobutylaluminium hydride in hexane; dichloromethane
T=-78°C; 2 h; Inert atmosphere;
参考文献
Yang, Dexi; Micalizio, Glenn C.
Journal of the American Chemical Society, 2011 , vol. 133, # 24 p. 9216 - 9219
反应条件
oxalyl dichloride; dimethyl sulfoxide; triethylamine
1.) CH2Cl2, -78 deg C, 1 h, 2.) CH2Cl2, a) -70 deg C, 1 h, b) RT, 2 h; Yield given. Multistep reaction;
参考文献
Khanna, Ish K.; Weier, Richard M.; Yu, Yi; Collins, Paul W.; Miyashiro, Julie M.; Koboldt, Carol M.; Veenhuizen, Amy W.; Currie, Jerry L.; Seibert, Karen; Isakson, Peter C.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 11 p. 1619 - 1633
