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结构式
乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
58707-50-9
合成路线
（共 5 条）
58707-50-9
→
反应条件
41639-83-2
拉坦前列腺素(游离酸)
反应条件
1.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere 2.1: sulfuric acid / water; methanol / 6 h / 20 °C 3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 4 h 4.1: triethylamine; lithium chloride / tetrahydrofuran / 1.5 h / -10 °C / Inert atmosphere 4.2: 2.42 h / -10 °C / Inert atmosphere 5.1: B-chloro-diisopinocampheylborane / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere 6.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 3.5 h / -78 °C / Inert atmosphere 6.2: -78 - 20 °C 7.1: tetrabutyl ammonium fluoride / water; tetrahydrofuran / 4 h / 0 °C 8.1: triethylamine; hydrogen / platinum on carbon / methanol / 24.25 h / 20 °C 9.1: potassium tert-butylate / tetrahydrofuran / 0.75 h / 0 °C / Inert atmosphere 9.2: -15 - -10 °C / Inert atmosphere View Scheme
参考文献
Newchem S.p.A.
Patent: EP2495235 A1, 2012 ;
58707-50-9
→
反应条件
352276-28-9
拉坦前列腺素内半缩醛
反应条件
1.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere 2.1: sulfuric acid / water; methanol / 6 h / 20 °C 3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 4 h 4.1: triethylamine; lithium chloride / tetrahydrofuran / 1.5 h / -10 °C / Inert atmosphere 4.2: 2.42 h / -10 °C / Inert atmosphere 5.1: B-chloro-diisopinocampheylborane / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere 6.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 3.5 h / -78 °C / Inert atmosphere 6.2: -78 - 20 °C 7.1: tetrabutyl ammonium fluoride / water; tetrahydrofuran / 4 h / 0 °C 8.1: triethylamine; hydrogen / platinum on carbon / methanol / 24.25 h / 20 °C View Scheme
参考文献
Newchem S.p.A.
Patent: EP2495235 A1, 2012 ;
58707-50-9
→
反应条件
130209-82-4
拉坦前列素
反应条件
1.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere 2.1: sulfuric acid / water; methanol / 6 h / 20 °C 3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 4 h 4.1: triethylamine; lithium chloride / tetrahydrofuran / 1.5 h / -10 °C / Inert atmosphere 4.2: 2.42 h / -10 °C / Inert atmosphere 5.1: B-chloro-diisopinocampheylborane / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere 6.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 3.5 h / -78 °C / Inert atmosphere 6.2: -78 - 20 °C 7.1: tetrabutyl ammonium fluoride / water; tetrahydrofuran / 4 h / 0 °C 8.1: triethylamine; hydrogen / platinum on carbon / methanol / 24.25 h / 20 °C 9.1: potassium tert-butylate / tetrahydrofuran / 0.75 h / 0 °C / Inert atmosphere 9.2: -15 - -10 °C / Inert atmosphere 10.1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 40 °C View Scheme
参考文献
Newchem S.p.A.
Patent: EP2495235 A1, 2012 ;
58707-50-9
→
反应条件
32233-40-2
(-)-6beta-羟甲基-7alpha-羟基-顺式-2-氧杂双环[3.3.0]辛-3-酮
反应条件
hydrogen; palladium on activated charcoal in dichloromethane T=20°C; 0.833333 h; atmospheric pressure;
参考文献
Kim, Seongjin; Jacobo, Sheila Marie; Chang, Chih-Tsung; Bellone, Sophie; Powell, William S.; Rokach, Joshua
Tetrahedron Letters, 2004 , vol. 45, # 9 p. 1973 - 1976
110-87-2
3,4-二氢-2H-吡喃
+
58707-50-9
→
反应条件
65025-95-8
(3aR,4S,5R,6aS)-4-[[[(1,1-二甲基乙基)二甲基硅基]氧基]甲基]六氢-5-[(四氢-2H-吡喃-2-基)氧基]-2H-环戊并[b]呋喃-2-酮
反应条件
toluene-4-sulfonic acid in dichloromethane T=20°C; 1 h; Inert atmosphere;
参考文献
Gonzalez-Gonzalez, Carlos A.; Fuentes-Benitez, Aydee; Cuevas-Yanez, Erick; Corona-Becerril, David; Gonzalez-Romero, Carlos; Gonzalez-Calderon, Davir
Tetrahedron Letters, 2013 , vol. 54, # 21 p. 2726 - 2728
