4-苄基-2-苯基-2-噁唑啉-5-酮合成路线 （共 38 条）
反应条件
1.1: 121 g / pyridine / H2O / 12 h / 20 °C 2.1: aq. NaOH / dioxane / 1 h / 20 °C 2.2: cinchonidine / ethanol / 6 h 2.3: 73.8 percent / aq. HCl / 0.5 h 3.1: 86.2 percent / pyridine / 72 h / 5 °C 4.1: 74.9 percent / NaI; Zn / dimethylformamide / 10 h / 120 °C 5.1: 82.1 percent / HCl / 10 h / Heating View Scheme
参考文献
Shiraiwa, Tadashi; Suzuki, Masahiro; Sakai, Yoshio; Nagasawa, Hisashi; Takatani, Kazuhiro; Noshi, Daisuke; Yamanashi, Kenji
Chemical and pharmaceutical bulletin, 2002 , vol. 50, # 10 p. 1362 - 1366
反应条件
water in various solvent(s) T=50°C; 35 h; Pseudomonas cepacia lipase; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Crich, Joyce Z.; Brieva, Rosario; Marquart, Peer; Gu, Rui-Lin; Flemming, Steffen; Sih, Charles J.
Journal of Organic Chemistry, 1993 , vol. 58, # 12 p. 3252 - 3258
反应条件
Candida antarctica lipase B cross-linked crystal; triethylamine in water; toluene T=37°C; 4 h; Title compound not separated from byproducts.;
参考文献
Quiros; Parker; Turner
Journal of Organic Chemistry, 2001 , vol. 66, # 15 p. 5074 - 5079
反应条件
18-crown-6 ether in benzene 24 h;
参考文献
Muneer, Mohammed; Tikare, Ravindra K.; Kamat, Prashant V.; George, Manapurathu V.
Canadian Journal of Chemistry, 1987 , vol. 65, p. 1624 - 1630
反应条件
water; oxonium T=25°C; different reaction conditions; solvent effect; Rate constantProduct distribution;
参考文献
Daffe, Viviane; Fastrez, Jacques
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1983 , p. 783 - 788
反应条件
1.1: 121 g / pyridine / H2O / 12 h / 20 °C 2.1: aq. NaOH / dioxane / 1 h / 20 °C 2.2: cinchonidine / ethanol / 6 h 2.3: aq. HCl / 0.5 h 3.1: 90 percent / pyridine / 72 h / 5 °C 4.1: 72.4 percent / NaI; Zn / dimethylformamide / 10 h / 120 °C 5.1: 80.3 percent / HCl / 10 h / Heating View Scheme
参考文献
Shiraiwa, Tadashi; Suzuki, Masahiro; Sakai, Yoshio; Nagasawa, Hisashi; Takatani, Kazuhiro; Noshi, Daisuke; Yamanashi, Kenji
Chemical and pharmaceutical bulletin, 2002 , vol. 50, # 10 p. 1362 - 1366
反应条件
tert-butylhypochlorite; potassium carbonate in tetrachloromethane 1) RT, 16 h; 2) reflux, 6.5 h;
参考文献
Lott, Richard S.; Breitholle, Edward G.; Stammer, Charles H.
Journal of Organic Chemistry, 1980 , vol. 45, # 6 p. 1151 - 1153
反应条件
water in various solvent(s) T=50°C; 35 h; Pseudomonas cepacia lipase; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Crich, Joyce Z.; Brieva, Rosario; Marquart, Peer; Gu, Rui-Lin; Flemming, Steffen; Sih, Charles J.
Journal of Organic Chemistry, 1993 , vol. 58, # 12 p. 3252 - 3258
反应条件
Candida antarctica lipase B cross-linked crystal; triethylamine in water; toluene T=37°C; 4 h; Title compound not separated from byproducts.;
参考文献
Quiros; Parker; Turner
Journal of Organic Chemistry, 2001 , vol. 66, # 15 p. 5074 - 5079
反应条件
18-crown-6 ether in benzene 24 h;
参考文献
Muneer, Mohammed; Tikare, Ravindra K.; Kamat, Prashant V.; George, Manapurathu V.
Canadian Journal of Chemistry, 1987 , vol. 65, p. 1624 - 1630
