4-甲氧基-4’-氰基联苯合成路线 （共 80 条）
反应条件
tetrabutylammomium bromide; N-ethyl-N,N-diisopropylamine; palladium diacetate in xylene T=130°C; 24 h;
参考文献
Tetrahedron, , vol. 57, # 37 p. 7845 - 7855
反应条件
bis-triphenylphosphine-palladium(II) chloride in acetonitrile; trifluoroacetic acid T=20°C; 1 h;
参考文献
Kazmierski, Igor; Gosmini, Corinne; Paris, Jean-Marc; Perichon, Jacques
Tetrahedron Letters, 2003 , vol. 44, # 34 p. 6417 - 6420
反应条件
K3PO4*3H2O in tetrahydrofuran; water Suzuki coupling; 6 h; Reflux;
参考文献
Kumar, V. K. Ratheesh; Krishnakumar, Sreedevi; Gopidas, Karical R.
European Journal of Organic Chemistry, 2012 , # 18 p. 3447 - 3458
反应条件
1: 4-hydroxy-benzonitrile With potassium phosphate; triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate in 1,4-dioxane T=100°C; 3 h; Inert atmosphere; 2: (4-methoxyphenyl)-boronic acid With [1,3-bis(diphenylphosphino) propane] dichloronickel(II) in 1,4-dioxane T=100 - 110°C; Suzuki-Miyaura coupling; Inert atmosphere;
参考文献
Chen, Guo-Jun; Huang, Jie; Gao, Lian-Xun; Han, Fu-She
Chemistry - A European Journal, 2011 , vol. 17, # 14 p. 4038 - 4042
反应条件
trimethylsilylazide; silver carbonate in dimethyl sulfoxide T=100°C; 12 h;
参考文献
Shen, Tao; Wang, Teng; Qin, Chong; Jiao, Ning
Angewandte Chemie - International Edition, 2013 , vol. 52, # 26 p. 6677 - 6680
Angew. Chem., 2013 , vol. 125, # 26 p. 6809 - 6612,4
反应条件
caesium carbonate; palladium dichloride in N,N-dimethyl-formamide T=185°C; 20 h; Inert atmosphereSealed tube;
参考文献
Synlett, , vol. 24, # 13 art. no. ST-2013-S0280-L, p. 1715 - 1721
反应条件
potassium phosphate; trans-[Ni(Naph)Cl(PPh3)2]; tri-cyclo-hexyl-phosphine in tetrahydrofuran T=25°C; Suzuki coupling; 26 h; Inert atmosphere;
参考文献
Leowanawat, Pawaret; Zhang, Na; Safi, Mehtap; Hoffman, David J.; Fryberger, Miriam C.; George, Aiswaria; Percec, Virgil
Journal of Organic Chemistry, 2012 , vol. 77, # 6 p. 2885 - 2892
反应条件
(Ph3P)2Pd(Ph)(I) in N,N-dimethyl-formamide 2 h; Heating;
参考文献
Bumagin, N. A.; Luzikova, E. V.; Beletskaya, I. P.
Russian Journal of Organic Chemistry, 1995 , vol. 31, # 11 p. 1480 - 1486
Zhurnal Organicheskoi Khimii, 1995 , vol. 31, # 11 p. 1650 - 1656
反应条件
palladium diacetate; cesium fluoride in tetrahydrofuran; 1,4-dioxane T=100°C; Suzuki-Miyaura coupling; 20 h;
参考文献
Organic Letters, , vol. 6, # 24 p. 4419 - 4422
反应条件
1: 93 percent Chromat. / 1,1'-bis(diphenylphosphino)ferrocene, KOAc / PdCl2(dppf) / dioxane / 13 h / 80 °C 2: 81 percent / KOAc / PdCl2(dppf) / dioxane / 24 h / 80 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 38, # 19 p. 3447 - 3450
