5-羟基-4-甲氧基-2-硝基苯甲醛合成路线 （共 12 条）
反应条件
sulfuric acid; nitric acid in water; acetic acid
参考文献
Japan Tobacco Inc.
Patent: US6017919 A1, 2000 ;
反应条件
nitric acid; acetic acid T=-5 - 30°C; 12 h;
参考文献
CIPLA LIMITED; CURTIS, Philip, Anthony
Patent: WO2008/125867 A2, 2008 ;
Location in patent: Page/Page column 25 ;
反应条件
hydrogenchloride; sodium nitrate; sodium chloride; sodium hydrogencarbonate in tetrahydrofuran; water
参考文献
Japan Tobacco Inc.
Patent: US6509352 B1, 2003 ;
反应条件
trifluoroacetic acid T=60°C; Yield given;
参考文献
Journal of Heterocyclic Chemistry, , vol. 24, p. 941 - 943
反应条件
sodium in methanol; dimethyl sulfoxide T=150°C; 0.0583333 h;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 40, # 7 p. 1691 - 1696
反应条件
1: fumic HNO3 / 1,2-dichloro-ethane / 3 h / -15 °C 2: CF3COOH / 60 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 24, p. 941 - 943
参考文献
Tetrahedron Letters, , vol. 37, # 32 p. 5751 - 5754
反应条件
sodium hydroxide und Erhitzen des Reaktionsprodukts mit wss.HCl;
参考文献
Journal of the Chemical Society, , p. 1244,1246
反应条件
1: 98 percent / 4-(dimethylamino)pyridine / 1 h
2: KF, 18-crown-8 / propan-2-ol / 5 h
3: acetic anhydride, sodium acetate / overnight
4: 94 percent / K2CO3 / ethanol / Ambient temperature
5: 43 percent / H2 / 10percent Pd/C / methanol / 2 h / 775.7 Torr
View Scheme
参考文献
Rogers, C. Bradford; Blum, Charles A.; Murphy, Bryan P.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 941 - 943
反应条件
potassium carbonate in N,N-dimethyl-formamide
4 h; Heating;
参考文献
Banwell, Martin G.; Hamel, Ernest; Ireland, Neil K.; Mackay, Maureen F.; Serelis, Algirdas K.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 16 p. 1905 - 1912
