(E)-N-[2-[2-[(2S)-1-甲基-2-哌啶基]乙基]苯基]-3-苯基-丙-2-烯酰胺合成路线 （共 4 条）
反应条件
1: S-APEMP.DBLT With sodium hydrogencarbonate in water; ethyl acetate
2: PhCH=CHCOCl With potassium carbonate in ethyl acetate
14 h; Reflux;
参考文献
SAM AMER and CO., INC.; AMER, Moh, Samir
Patent: WO2012/26914 A1, 2012 ;
Location in patent: Page/Page column 13 ;
WO 2012/026914 A1
反应条件
1.1: acetic anhydride / 27 h / Inert atmosphere; Reflux
2.1: acetone / 18 h / Inert atmosphere; Reflux
3.1: hydrogen / palladium 10 on activated carbon / methanol
4.1: sodium hydroxide / ethyl acetate; water
4.2: 20 °C
5.1: sodium hydrogencarbonate / ethyl acetate; water
5.2: 14 h / Reflux
View Scheme
参考文献
SAM AMER and CO., INC.; AMER, Moh, Samir
Patent: WO2012/26914 A1, 2012 ;
WO 2012/026914 A1
反应条件
1.1: acetic anhydride / 27 h / Inert atmosphere; Reflux
2.1: acetone / 18 h / Inert atmosphere; Reflux
3.1: hydrogen / palladium 10 on activated carbon / methanol
4.1: sodium hydroxide / ethyl acetate; water
4.2: 20 °C
5.1: sodium hydrogencarbonate / ethyl acetate; water
5.2: 14 h / Reflux
View Scheme
参考文献
SAM AMER and CO., INC.; AMER, Moh, Samir
Patent: WO2012/26914 A1, 2012 ;
WO 2012/026914 A1
反应条件
1.1: acetone / 18 h / Inert atmosphere; Reflux
2.1: hydrogen / palladium 10 on activated carbon / methanol
3.1: sodium hydroxide / ethyl acetate; water
3.2: 20 °C
4.1: sodium hydrogencarbonate / ethyl acetate; water
4.2: 14 h / Reflux
View Scheme
参考文献
SAM AMER and CO., INC.; AMER, Moh, Samir
Patent: WO2012/26914 A1, 2012 ;
WO 2012/026914 A1
