反应条件
1: 2,7-tBu2-fluorene With n-butyllithium in tetrahydrofuran; hexane
T=0 - 5°C; Metallation; 0.133333 h;
2: formaldehyd in tetrahydrofuran; hexane
T=0 - 20°C; hydroxymethylation; 0.833333 h; Further stages.;
参考文献
Stigers, Kimberly D.; Koutroulis, Mathew R.; Chung, De Michael; Nowick, James S.
Journal of Organic Chemistry, 2000 , vol. 65, # 12 p. 3858 - 3859