反应条件
1: (+/-)-N2-(4-methoxyphenyl)-1,1,1-trifluoro-3-phenylsulfonyl-2-propanamine With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 2 h;
2: chloromethyl iodide in tetrahydrofuran; hexane
0.166667 h;
3: With methyllithium in tetrahydrofuran; hexane
Julia methylenation-desulfonylation; 0.25 h;
参考文献
Fustero, Santos; Garcia Soler, Juan; Bartolome, Ana; Sanchez Rosello, Maria
Organic Letters, 2003 , vol. 5, # 15 p. 2707 - 2710