1-甲基-4-氮杂芴-9-酮合成路线 （共 24 条）
反应条件
sodium hydroxide; oxygen in dimethyl sulfoxide
T=30 - 40°C; 3 h;
参考文献
Prostakov, N. S.; Soldatenkov, A. T.; Radzhan, P. K.; Fedorov, V. O.; Fomichev, A. A.; Rezakov, V. A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1982 , vol. 18, # 4 p. 390 - 394
Khimiya Geterotsiklicheskikh Soedinenii, 1982 , vol. 18, # 4 p. 513 - 517
反应条件
palladium 10 on activated carbon; hydrogen; sodium acetate in methanol
P=760.051 Torr;
参考文献
Zhang, Song; Liao, Lian-Yan; Zhang, Fang; Duan, Xin-Fang
Journal of Organic Chemistry, 2013 , vol. 78, # 6 p. 2720 - 2725
反应条件
PPA
T=130 - 140°C; 4 h;
参考文献
Bracher, Franz
Archiv der Pharmazie (Weinheim, Germany), 1989 , vol. 322, p. 293 - 294
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium carbonate in 1,4-dioxane
18 h; Heating;
参考文献
Rebstock, Anne-Sophie; Mongin, Florence; Trecourt, Francois; Queguiner, Guy
Tetrahedron, 2004 , vol. 60, # 10 p. 2181 - 2186
反应条件
tetrabutyl-ammonium chloride; palladium diacetate; sodium carbonate in N,N-dimethyl-formamide
T=130°C; Heck reaction; 3 h; Inert atmosphere;
参考文献
Kraus, George A.; Kempema, Aaron
Journal of Natural Products, 2010 , vol. 73, # 11 p. 1967 - 1968
反应条件
in quinoline
T=170 - 180°C; 72 h;
参考文献
Tong; Wong
Synthetic Communications, 1992 , vol. 22, # 12 p. 1773 - 1782
反应条件
1: 91 percent / benzene / 12 h / Heating
2: 99 percent / NaIO4 / methanol; H2O / 3 h
3: 81 percent / p-toluenesulfonic acid / toluene / 1 h / Heating
4: K2CO3 / methanol / 3 h / 20 °C
5: 1.9 g / Et3N / CH2Cl2 / 12 h
6: 97 percent / Pd(PPh3)2Cl2; Et3N; formic acid / dimethylformamide / 1 h / 110 °C
7: trifluoroacetic acid / 1 h / 100 °C
8: 0.7 g / pyridine / 2 h / 0 °C
9: 75 percent / Pd(PPh3)2Cl2; Et3N; formic acid / dimethylformamide / 1 h / 110 °C
10: 68 percent / potassium permanganate / acetone / 3 h / 20 °C
View Scheme
参考文献
Padwa, Albert; Heidelbaugh, Todd M.; Kuethe, Jeffrey T.
Journal of Organic Chemistry, 2000 , vol. 65, # 8 p. 2368 - 2378
反应条件
1: 75 percent / Pd(PPh3)2Cl2; Et3N; formic acid / dimethylformamide / 1 h / 110 °C
2: 68 percent / potassium permanganate / acetone / 3 h / 20 °C
View Scheme
参考文献
Padwa, Albert; Heidelbaugh, Todd M.; Kuethe, Jeffrey T.
Journal of Organic Chemistry, 2000 , vol. 65, # 8 p. 2368 - 2378
反应条件
1: trifluoroacetic acid / 1 h / 100 °C
2: 0.7 g / pyridine / 2 h / 0 °C
3: 75 percent / Pd(PPh3)2Cl2; Et3N; formic acid / dimethylformamide / 1 h / 110 °C
4: 68 percent / potassium permanganate / acetone / 3 h / 20 °C
View Scheme
参考文献
Padwa, Albert; Heidelbaugh, Todd M.; Kuethe, Jeffrey T.
Journal of Organic Chemistry, 2000 , vol. 65, # 8 p. 2368 - 2378
反应条件
1: 1.9 g / Et3N / CH2Cl2 / 12 h
2: 97 percent / Pd(PPh3)2Cl2; Et3N; formic acid / dimethylformamide / 1 h / 110 °C
3: trifluoroacetic acid / 1 h / 100 °C
4: 0.7 g / pyridine / 2 h / 0 °C
5: 75 percent / Pd(PPh3)2Cl2; Et3N; formic acid / dimethylformamide / 1 h / 110 °C
6: 68 percent / potassium permanganate / acetone / 3 h / 20 °C
View Scheme
参考文献
Padwa, Albert; Heidelbaugh, Todd M.; Kuethe, Jeffrey T.
Journal of Organic Chemistry, 2000 , vol. 65, # 8 p. 2368 - 2378
