4-(4-(2,3-二羟基丙氧基)苯基)丁基氨基甲酸苄酯合成路线 （共 8 条）
反应条件
hydrogenchloride; sodium hydrogen sulphate; osmium(VIII) oxide in water; acetone; tert-butyl alcohol
参考文献
CYFI, INC.
Patent: US2003/199456 A1, 2003 ;
US 20030199456 A1
反应条件
triethylamine in ethanol
2 h; Heating;
参考文献
Hirsh, Andrew J.; Molino, Bruce F.; Zhang, Jianzhong; Astakhova, Nadezhda; Geiss, William B.; Sargent, Bruce J.; Swenson, Brian D.; Usyatinsky, Alexander; Wyle, Michael J.; Boucher, Richard C.; Smith, Rick T.; Zamurs, Andra; Johnson, M. Ross
Journal of Medicinal Chemistry, 2006 , vol. 49, # 14 p. 4098 - 4115
反应条件
1: 94 percent / Ph3P; H2O / tetrahydrofuran / 20 °C
2: 90 percent / aq. HBr / 3 h / Heating
3: 62 percent / sodium bicarbonate / dioxane; H2O / -2 - 20 °C
4: 58 percent / triethylamine / ethanol / 2 h / Heating
View Scheme
参考文献
Hirsh, Andrew J.; Molino, Bruce F.; Zhang, Jianzhong; Astakhova, Nadezhda; Geiss, William B.; Sargent, Bruce J.; Swenson, Brian D.; Usyatinsky, Alexander; Wyle, Michael J.; Boucher, Richard C.; Smith, Rick T.; Zamurs, Andra; Johnson, M. Ross
Journal of Medicinal Chemistry, 2006 , vol. 49, # 14 p. 4098 - 4115
反应条件
1: pyridine / tetrahydrofuran / 20 °C
2: sodium azide / dimethylformamide / 20 °C
3: 94 percent / Ph3P; H2O / tetrahydrofuran / 20 °C
4: 90 percent / aq. HBr / 3 h / Heating
5: 62 percent / sodium bicarbonate / dioxane; H2O / -2 - 20 °C
6: 58 percent / triethylamine / ethanol / 2 h / Heating
View Scheme
参考文献
Hirsh, Andrew J.; Molino, Bruce F.; Zhang, Jianzhong; Astakhova, Nadezhda; Geiss, William B.; Sargent, Bruce J.; Swenson, Brian D.; Usyatinsky, Alexander; Wyle, Michael J.; Boucher, Richard C.; Smith, Rick T.; Zamurs, Andra; Johnson, M. Ross
Journal of Medicinal Chemistry, 2006 , vol. 49, # 14 p. 4098 - 4115
反应条件
1.1: 4-methylmorpholine; isobutylchloroformate / tetrahydrofuran / 0.5 h / -20 - -10 °C
1.2: 97 percent / NH3 / methanol; tetrahydrofuran
2.1: borane / tetrahydrofuran / 3 h / Heating
3.1: 90 percent / aq. HBr / 3 h / Heating
4.1: 62 percent / sodium bicarbonate / dioxane; H2O / -2 - 20 °C
5.1: 58 percent / triethylamine / ethanol / 2 h / Heating
View Scheme
参考文献
Hirsh, Andrew J.; Molino, Bruce F.; Zhang, Jianzhong; Astakhova, Nadezhda; Geiss, William B.; Sargent, Bruce J.; Swenson, Brian D.; Usyatinsky, Alexander; Wyle, Michael J.; Boucher, Richard C.; Smith, Rick T.; Zamurs, Andra; Johnson, M. Ross
Journal of Medicinal Chemistry, 2006 , vol. 49, # 14 p. 4098 - 4115
反应条件
1: 90 percent / aq. HBr / 3 h / Heating
2: 62 percent / sodium bicarbonate / dioxane; H2O / -2 - 20 °C
3: 58 percent / triethylamine / ethanol / 2 h / Heating
View Scheme
参考文献
Hirsh, Andrew J.; Molino, Bruce F.; Zhang, Jianzhong; Astakhova, Nadezhda; Geiss, William B.; Sargent, Bruce J.; Swenson, Brian D.; Usyatinsky, Alexander; Wyle, Michael J.; Boucher, Richard C.; Smith, Rick T.; Zamurs, Andra; Johnson, M. Ross
Journal of Medicinal Chemistry, 2006 , vol. 49, # 14 p. 4098 - 4115
反应条件
1: borane / tetrahydrofuran / 3 h / Heating
2: 90 percent / aq. HBr / 3 h / Heating
3: 62 percent / sodium bicarbonate / dioxane; H2O / -2 - 20 °C
4: 58 percent / triethylamine / ethanol / 2 h / Heating
View Scheme
参考文献
Hirsh, Andrew J.; Molino, Bruce F.; Zhang, Jianzhong; Astakhova, Nadezhda; Geiss, William B.; Sargent, Bruce J.; Swenson, Brian D.; Usyatinsky, Alexander; Wyle, Michael J.; Boucher, Richard C.; Smith, Rick T.; Zamurs, Andra; Johnson, M. Ross
Journal of Medicinal Chemistry, 2006 , vol. 49, # 14 p. 4098 - 4115
反应条件
1: sodium azide / dimethylformamide / 20 °C
2: 94 percent / Ph3P; H2O / tetrahydrofuran / 20 °C
3: 90 percent / aq. HBr / 3 h / Heating
4: 62 percent / sodium bicarbonate / dioxane; H2O / -2 - 20 °C
5: 58 percent / triethylamine / ethanol / 2 h / Heating
View Scheme
参考文献
Hirsh, Andrew J.; Molino, Bruce F.; Zhang, Jianzhong; Astakhova, Nadezhda; Geiss, William B.; Sargent, Bruce J.; Swenson, Brian D.; Usyatinsky, Alexander; Wyle, Michael J.; Boucher, Richard C.; Smith, Rick T.; Zamurs, Andra; Johnson, M. Ross
Journal of Medicinal Chemistry, 2006 , vol. 49, # 14 p. 4098 - 4115
