4,8-二溴-2-(三氟甲基)-喹啉合成路线 （共 4 条）
反应条件
n-butyllithium in tetrahydrofuran; hexane T=-75°C; 0.25 h;
参考文献
Cottet, Fabrice; Marull, Marc; Lefebvre, Olivier; Schlosser, Manfred
European Journal of Organic Chemistry, 2003 , # 8 p. 1559 - 1568
反应条件
1: 69 percent / butyllithium; iodine / tetrahydrofuran; hexane / 0.75 h / -75 °C 2: 45 percent / isopropylmagnesium chloride / tetrahydrofuran / 0.75 h / 0 °C 3: 100 percent / zinc; sodium hydroxide / H2O / 2 h / 0 °C View Scheme
参考文献
Marull, Marc; Schlosser, Manfred
European Journal of Organic Chemistry, 2003 , # 8 p. 1576 - 1588
反应条件
phosphorus oxytribromide
T=150°C; 2 h;
参考文献
Marull, Marc; Schlosser, Manfred
European Journal of Organic Chemistry, 2003 , # 8 p. 1576 - 1588
反应条件
1: 64 percent / polyphosphoric acid / 2 h / 150 °C
2: 83 percent / phosphorus oxybromide / 2 h / 150 °C
View Scheme
参考文献
Marull, Marc; Schlosser, Manfred
European Journal of Organic Chemistry, 2003 , # 8 p. 1576 - 1588
