1-乙基-4-硝基-1H-吡唑合成路线 （共 6 条）
反应条件
1: 4-nitropyrazole With sodium hydride in N,N-dimethyl-formamide; mineral oil T=-25°C; 0.5 h; 2: ethyl bromide in N,N-dimethyl-formamide; mineral oil T=-25°C; 6 h;
参考文献
GENENTECH, INC.; Crawford, James John; Ortwine, Daniel Fred; Wei, BinQing; Young, Wendy B.
Patent: US2013/116246 A1, 2013 ;
Location in patent: Paragraph 0354; 0355 ;
反应条件
sodium hydroxide in water T=30°C; 48 h;
参考文献
WO2006/40520 A1, ;
Page/Page column 123 ;
WO 2006/040520 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C;
参考文献
WO2006/17443 A2, ;
Page/Page column 123 ;
WO 2006/017443 A2
反应条件
hydrogen; palladium 10 on activated carbon in ethanol P=2585.81 Torr; 3 h; Inert atmosphere;
参考文献
GILEAD CONNECTICUT, INC.; GENENTECH, INC.; CURRIE, Kevin S.; WANG, Xiaojing; YOUNG, Wendy B.
Patent: WO2012/31004 A1, 2012 ;
Location in patent: Page/Page column 84-85 ;
WO 2012/031004 A1
参考文献
Genentech, Inc.; Burch, Jason; Sun, Minghua; Wang, Xiaojing; Blackaby, Wesley; Hodges, Alastair James; Sharpe, Andrew
Patent: US2014/88117 A1, 2014 ;
Location in patent: Page/Page column ;
参考文献
Genentech, Inc.; Burch, Jason; Sun, Minghua; Wang, Xiaojing; Blackaby, Wesley; Hodges, Alastair James; Sharpe, Andrew
Patent: US2014/88117 A1, 2014 ;
Location in patent: Page/Page column ;
