2,2,2-三氟-1-(4-硝基苯基)-乙酮(9ci)合成路线 （共 12 条）
反应条件
Oxonereg;; sodium 2-iodobenzenesulfonate in acetonitrile
T=90°C; 18 h;
参考文献
Tanaka, Yusuke; Ishihara, Takashi; Konno, Tsutomu
Journal of Fluorine Chemistry, 2012 , vol. 137, p. 99 - 104
反应条件
hydrogenchloride in 1,4-dioxane; water
参考文献
Cell Therapeutics, Inc.
Patent: US2004/204386 A1, 2004 ;
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran; dichloromethane
18 h; Ambient temperature;
参考文献
Wiedemann, Juergen; Heiner, Thomas; Mloston, Gregorz; Prakash, G.K. Surya; Olah, George A.
Angewandte Chemie - International Edition, 1998 , vol. 37, # 6 p. 820 - 821
反应条件
2,6-dimethylpyridine; oxoammonium salt in dichloromethane
T=20°C; Sealed tube;
参考文献
Cheng, Huicheng; Pei, Yu; Leng, Faqiang; Li, Jingya; Liang, Apeng; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng
Tetrahedron Letters, 2013 , vol. 54, # 33 p. 4483 - 4486
反应条件
1: (trifluoromethyl)-trimethylsilane With silver monofluoride
T=20°C; 2 h;
2: 4-nitro-benzoyl chloride With 4-(N,N-dimethlyamino)pyridine in dichloromethane
T=20°C; 72 h; Further stages.;
参考文献
Kremlev, Mikhail M.; Mushta, Aleksej I.; Tyrra, Wieland; Naumann, Dieter; Fischer, Hendrik T.M.; Yagupolskii, Yurii L.
Journal of Fluorine Chemistry, 2007 , vol. 128, # 11 p. 1385 - 1389
反应条件
dicyclohexyl-carbodiimide in dichloromethane
T=20°C;
参考文献
Kremlev, Mikhail M.; Mushta, Aleksej I.; Tyrra, Wieland; Naumann, Dieter; Fischer, Hendrik T.M.; Yagupolskii, Yurii L.
Journal of Fluorine Chemistry, 2007 , vol. 128, # 11 p. 1385 - 1389
反应条件
4-(N,N-dimethlyamino)pyridine; bis(trifluoromethyl)cadmium*glyme in dichloromethane
72 h; Ambient temperature;
参考文献
Naumann, Dieter; Finke, Martina; Lange, Horst; Dukat, Wolfgang; Tyrra, Wieland
Journal of Fluorine Chemistry, 1992 , vol. 56, # 2 p. 215 - 237
反应条件
4-(N,N-dimethlyamino)pyridine in dichloromethane
72 h; Ambient temperature;
参考文献
Naumann, Dieter; Finke, Martina; Lange, Horst; Dukat, Wolfgang; Tyrra, Wieland
Journal of Fluorine Chemistry, 1992 , vol. 56, # 2 p. 215 - 237
反应条件
1.1: tetrahydrofuran / 0.17 h / 0 °C / |Inert atmosphere; |Sealed tube
1.2: 0 - 20 °C / |Inert atmosphere; |Sealed tube
1.3: 0 - 20 °C / |Inert atmosphere; |Sealed tube
2.1: oxoammonium salt; 2,6-dimethylpyridine / dichloromethane / 20 °C / |Sealed tube
View Scheme
参考文献
Kelly, Christopher B.; Mercadante, Michael A.; Hamlin, Trevor A.; Fletcher, Madison H.; Leadbeater, Nicholas E.
Journal of Organic Chemistry, 2012 , vol. 77, # 18 p. 8131 - 8141
反应条件
T=0°C; 6 h; Further byproducts given;
参考文献
Naumann, Dieter; Finke, Martina; Lange, Horst; Dukat, Wolfgang; Tyrra, Wieland
Journal of Fluorine Chemistry, 1992 , vol. 56, # 2 p. 215 - 237
