methyl-phenyl-thioether; trifluoroacetic acid T=28°C; 24 h; var. reag.: dimethylsulfide, ethanedithiol, 2-mercaptoethanol; var. time; Product distribution;

2: 61 percent / N-methylmorpholine / dimethylformamide; tetrahydrofuran / 3 h 3: 89 percent / N-methylmorpholine, HOBt, DCC / dimethylformamide / 16 h 4: 67 percent / TFMSA-thioanisole, ethanedithiol / trifluoroacetic acid / 1 h View Scheme

Multi-step reaction with 2 steps 2: 61 percent / N-methylmorpholine / dimethylformamide; tetrahydrofuran / 3 h