2 6-二甲氧基吡啶-3-羧醛合成路线 （共 10 条）
反应条件
1: 3-bromo-2,6-dimethoxypyridine With n-butyllithium in tetrahydrofuran T=-78°C; 1 h; 2: N,N-dimethyl-formamide in tetrahydrofuran 2 h; Further stages.;
参考文献
Hu, Laixing; Li, Zhuo-rong; Wang, Yue-ming; Wu, Yanbin; Jiang, Jian-Dong; Boykin, David W.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 5 p. 1193 - 1196
反应条件
1.1: 77 percent / N-bromosuccinimide; pyridine / acetonitrile / 2 h / 0 °C 2.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C 2.2: 71 percent / tetrahydrofuran / 2 h View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 5 p. 1193 - 1196
参考文献
Dainter, Ronald S.; Suschitzky, Hans; Wakefield, Basil J.; Hughes, Nigel; Nelson, Anthony J.
Tetrahedron Letters, 1984 , vol. 25, # 49 p. 5693 - 5696
反应条件
sodium 6 h; Heating;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 283 - 287
反应条件
methanol; diisobutylaluminum hydride in toluene 1 h; Ambient temperature;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 283 - 287
反应条件
1: 71 percent / sodium / 1 h / Ambient temperature 2: di-isobutylaluminium hydride, methanol / toluene / 1 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 283 - 287
反应条件
in tetrahydrofuran 15 h; Heating;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 283 - 287
反应条件
n-butyllithium; iodobenzene; diisopropylamine 1.) THF, 20 deg C, 3 h, 2.) -40 deg C, 30 min.; Yield given. Multistep reaction;
参考文献
Journal of Organometallic Chemistry, , vol. 406, # 1+2 p. 49 - 56
反应条件
sodium tetrahydroborate in methanol T=0°C; 2 h;
参考文献
Hu, Laixing; Li, Zhuo-rong; Wang, Yue-ming; Wu, Yanbin; Jiang, Jian-Dong; Boykin, David W.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 5 p. 1193 - 1196
反应条件
1: 89 percent / NaBH4 / methanol / 2 h / 0 °C
2: 74 percent / PBr3 / CH2Cl2 / 12 h / 0 °C
View Scheme
参考文献
Hu, Laixing; Li, Zhuo-rong; Wang, Yue-ming; Wu, Yanbin; Jiang, Jian-Dong; Boykin, David W.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 5 p. 1193 - 1196
