1: 6-bromo-3-iodo-2-methoxypyridine With n-butyllithium in diethyl ether T=-80°C; 1 h; Inert atmosphere; 2: N,N-dimethyl-formamide in diethyl ether T=-80°C; 1 h; Inert atmosphere; 3: With water in diethyl ether T=-80°C;

1.1: hydrogen / palladium 10 on activated carbon / methanol / 4 h 2.1: N-bromosuccinmide / N,N-dimethyl-formamide / -30 °C 3.1: hydrogenchloride; sodium nitrite / water / 0.33 h / 5 °C 3.2: 5 - 60 °C 4.1: n-butyllithium / diethyl ether / 1 h / -80 °C / Inert atmosphere 4.2: 1 h / -80 °C / Inert atmosphere 4.3: -80 °C View Scheme

1.1: N-bromosuccinmide / N,N-dimethyl-formamide / -30 °C 2.1: hydrogenchloride; sodium nitrite / water / 0.33 h / 5 °C 2.2: 5 - 60 °C 3.1: n-butyllithium / diethyl ether / 1 h / -80 °C / Inert atmosphere 3.2: 1 h / -80 °C / Inert atmosphere 3.3: -80 °C View Scheme

1.1: hydrogenchloride; sodium nitrite / water / 0.33 h / 5 °C 1.2: 5 - 60 °C 2.1: n-butyllithium / diethyl ether / 1 h / -80 °C / Inert atmosphere 2.2: 1 h / -80 °C / Inert atmosphere 2.3: -80 °C View Scheme