1H-苯并咪唑-6-羧酸乙酯合成路线 （共 4 条）
反应条件
hydrazine hydrate in methanol 10 h; Reflux;
参考文献
Cong, Chao; Wang, Haiyang; Hu, Yue; Liu, Chen; Ma, Siti; Li, Xin; Cao, Jichao; Ma, Shutao
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 3105 - 3111
反应条件
sodium hydroxide; diisobutylaluminium hydride in methanol; dichloromethane
参考文献
Merck and Co., Inc.
Patent: US6610692 B1, 2003 ;
US 6610692 B1
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 18 h; Heating;
参考文献
Deghati, Paymaneh Y. F.; Borghini, Alice; Van Den Nieuwendijk, Adrianus M. C. H.; Dissen-de Groote, Miriam; IJzerman, Adriaan P.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 6 p. 899 - 908
反应条件
1: hydrazine hydrate / ethanol / 48 h / |Reflux
2: potassium hydroxide / ethanol; water / 10 h / |Reflux
3: triethylamine / ethanol / |Reflux
View Scheme
参考文献
Ramsbeck, Daniel; Buchholz, Mirko; Koch, Birgit; Boehme, Livia; Hoffmann, Torsten; Demuth, Hans-Ulrich; Heiser, Ulrich
Journal of Medicinal Chemistry, 2013 , vol. 56, # 17 p. 6613 - 6625
