1a,2,7,7a-四氢-3,6-二甲氧基-萘并[2,3-b]环氧乙烯合成路线 （共 10 条）
反应条件
magnesium bromide in toluene 6 h; Heating;
参考文献
Tririya, Gasirat; Zanger, Murray
Synthetic Communications, 2004 , vol. 34, # 17 p. 3047 - 3059
反应条件
sodium hydroxide in ethanol 1.) 60-65 deg C, 1 h, 2.) 80-85 deg C, 6 h; Yields of byproduct given;
参考文献
Archiv der Pharmazie, , vol. 320, # 7 p. 625 - 629
反应条件
3-chloro-benzenecarboperoxoic acid in dichloromethane
T=20°C; 12 h;
参考文献
Tririya, Gasirat; Zanger, Murray
Synthetic Communications, 2004 , vol. 34, # 17 p. 3047 - 3059
反应条件
3-chloro-benzenecarboperoxoic acid in hexane; dichloromethane
参考文献
Eli Lilly and Company
Patent: US5026707 A1, 1991 ;
US 5026707 A
反应条件
1: 91 percent / AcOH; aq. HBr / 0.25 h / 110 - 115 °C
2: 68 percent / NaOH / H2O / 12 h / 20 °C
3: 91 percent / m-CPBA / CH2Cl2 / 12 h / 20 °C
View Scheme
参考文献
Tririya, Gasirat; Zanger, Murray
Synthetic Communications, 2004 , vol. 34, # 17 p. 3047 - 3059
反应条件
1: 68 percent / NaOH / H2O / 12 h / 20 °C
2: 91 percent / m-CPBA / CH2Cl2 / 12 h / 20 °C
View Scheme
参考文献
Tririya, Gasirat; Zanger, Murray
Synthetic Communications, 2004 , vol. 34, # 17 p. 3047 - 3059
反应条件
1: 88 percent / toluene / 120 h
2: 91 percent / AcOH; aq. HBr / 0.25 h / 110 - 115 °C
3: 68 percent / NaOH / H2O / 12 h / 20 °C
4: 91 percent / m-CPBA / CH2Cl2 / 12 h / 20 °C
View Scheme
参考文献
Tririya, Gasirat; Zanger, Murray
Synthetic Communications, 2004 , vol. 34, # 17 p. 3047 - 3059
反应条件
lithium aluminium tetrahydride in diethyl ether
5 h; Heating;
参考文献
Arvidsson; Hacksell; Johansson; Nilsson; Lindberg; Sanchez; Wikstroem; Svensson; Hjorth; Carlsson
Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 45 - 51
参考文献
Dantchev; Christova; Staneva; Rainova; Tschakarova
Archiv der Pharmazie, 1977 , vol. 310, # 5 p. 369 - 379
反应条件
1: 42 percent / MgBr2*Et2O / toluene / 6 h / Heating
2: 54 percent / AlCl3; NaCl / 180 °C
View Scheme
参考文献
Tririya, Gasirat; Zanger, Murray
Synthetic Communications, 2004 , vol. 34, # 17 p. 3047 - 3059
