4-氨基-1-哌啶甲酸乙酯合成路线 （共 33 条）
反应条件
sodium carbonate; potassium iodide in cyclohexanol
T=180°C; 0.166667 h; microwave irradiation;
参考文献
Burgey, Christopher S.; Stump, Craig A.; Nguyen, Diem N.; Deng, James Z.; Quigley, Amy G.; Norton, Beth R.; Bell, Ian M.; Mosser, Scott D.; Salvatore, Christopher A.; Rutledge, Ruth Z.; Kane, Stefanie A.; Koblan, Kenneth S.; Vacca, Joseph P.; Graham, Samuel L.; Williams, Theresa M.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 19 p. 5052 - 5056
反应条件
1: 65 percent / Na2CO3, KI / various solvent(s) / 28 h / 160 °C
2: 93 percent / H2 / Raney Ni / ethanol; tetrahydrofuran / 1 h / Ambient temperature
3: 90 percent / Et3N / CH2Cl2 / 0.5 h / 0 °C
View Scheme
参考文献
Burgey, Christopher S.; Stump, Craig A.; Nguyen, Diem N.; Deng, James Z.; Quigley, Amy G.; Norton, Beth R.; Bell, Ian M.; Mosser, Scott D.; Salvatore, Christopher A.; Rutledge, Ruth Z.; Kane, Stefanie A.; Koblan, Kenneth S.; Vacca, Joseph P.; Graham, Samuel L.; Williams, Theresa M.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 19 p. 5052 - 5056
反应条件
1: dimethylformamide / 60 °C
2: NH4HCO2 / Pt/C / ethanol / 20 °C
3: Et3N / CH2Cl2 / 20 °C
View Scheme
参考文献
Burgey, Christopher S.; Stump, Craig A.; Nguyen, Diem N.; Deng, James Z.; Quigley, Amy G.; Norton, Beth R.; Bell, Ian M.; Mosser, Scott D.; Salvatore, Christopher A.; Rutledge, Ruth Z.; Kane, Stefanie A.; Koblan, Kenneth S.; Vacca, Joseph P.; Graham, Samuel L.; Williams, Theresa M.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 19 p. 5052 - 5056
