反应条件
1: 2,2,2-trifluoroethanol With potassium hydroxide; Aliquatreg; 336 in dichloromethane T=30°C; 0.25 h; Inert atmosphere; 2: methyl 6-{[(methylsulfonyl)oxy]methyl}pyridine-3-carboxylate in dichloromethane 0.25 h;
参考文献
ASTRAZENECA AB; AURELL, Carl-Johan; BESIDSKI, Yevgeni; KERS, Inger; NYLOeF, Martin
Patent: WO2012/39657 A1, 2012 ;
Location in patent: Page/Page column 14 ;
WO 2012/039657 A1