1-(2,4-二甲基-3-吡啶基)甲胺合成路线 （共 4 条）
反应条件
hydrogen; PtO2/C in ethanol
T=20°C; P=3040.2 Torr; 0.5 h;
参考文献
JAPAN TOBACCO INC.
Patent: WO2006/126695 A1, 2006 ;
Location in patent: Page/Page column 260 ;
参考文献
Japan Tobacco Inc.
Patent: US2007/32529 A1, 2007 ;
US 20070032529 A1
反应条件
1: diisobutylaluminium hydride / dichloromethane / 2 h / -70 °C
2: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 0 - 20 °C
3: palladium 10 on activated carbon; hydrogen / methanol / 3 h
View Scheme
参考文献
NOVARTIS AG; FLOHR, Stefanie; MARKERT, Christian; NAMOTO, Kenji; PIRARD, Bernard
Patent: WO2013/111108 A1, 2013 ;
反应条件
1: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 0 - 20 °C
2: palladium 10 on activated carbon; hydrogen / methanol / 3 h
View Scheme
参考文献
NOVARTIS AG; FLOHR, Stefanie; MARKERT, Christian; NAMOTO, Kenji; PIRARD, Bernard
Patent: WO2013/111108 A1, 2013 ;
