3-氨基-5-溴-2-氯吡啶合成路线 （共 13 条）
反应条件
1: With hydrogenchloride; water; tin(ll) chloride T=20°C; 20 h; 2: With sodium hydroxide in water T=0°C;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/157191 A2, 2008 ;
Location in patent: Page/Page column 75 ;
WO 2008/157191 A2
反应条件
potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in 1,4-dioxane T=100°C; 18 h;
参考文献
CHAUDHARI, Amita; DHANAK, Dashyant; DONATELLI, Carla Ann; FAITG, Thomas H.; FENG, Yanhong; KNIGHT, Steven David; PARRISH, Cynthia A.; RALPH, Jeffrey M.
Patent: US2008/293706 A1, 2008 ;
Location in patent: Page/Page column 85 ;
US 20080293706 A1
反应条件
1: 36 percent / tBuNO; CuCl2 / acetonitrile / 2 h / Heating 2: 87 percent / SnCl2*2H2O / ethyl acetate / 3 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 40, # 2 p. 261 - 268
反应条件
1: trichlorophosphate / N,N-dimethyl-formamide / 2 h / Reflux 2: ethanol; tin(ll) chloride / 1 h / Reflux View Scheme
参考文献
US2012/238587 A1, ;
US 20120238587 A1
反应条件
hydrogenchloride; tin
参考文献
Journal of the Chemical Society, , p. 2042,2044
参考文献
Journal of the Chemical Society, , p. 2042,2044
参考文献
Journal of the Chemical Society, , p. 2042,2044
反应条件
pyridine in dichloromethane T=20°C; 18.0833 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2009/39140 A1, 2009 ;
Location in patent: Page/Page column 49-50 ;
WO 2009/039140 A1
反应条件
pyridine in dichloromethane T=20°C; 72 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2009/55418 A1, 2009 ;
Location in patent: Page/Page column 53-54 ;
WO 2009/055418 A1
反应条件
hydrogenchloride; copper; sodium nitrite Diazotization;
参考文献
Berrie et al.
Journal of the Chemical Society, 1952 , p. 2042,2044
