3-氨基-5-溴-2-氯吡啶合成路线 （共 13 条）
反应条件
potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in ethylene glycol dimethyl ether T=80°C; Suzuki Coupling; Inert atmosphere;
参考文献
WO2010/8847 A2, ;
Page/Page column 143-144 ;
反应条件
1: 5-bromo-2-chloro-pyridin-3-ylamine With hydrogenchloride in water Sonicated; 2: potassium thioacyanate in water T=100°C; 6.5 h; Reflux; 3: With sodium carbonate in water
参考文献
WO2009/147431 A1, ;
Page/Page column 51; 52 ;
WO 2009/147431 A1
反应条件
1: 5-bromo-2-chloro-pyridin-3-ylamine With n-butyllithium in tetrahydrofuran; hexane
T=0°C; 0.5 h;
2: methyl iodide in tetrahydrofuran; hexane
T=20°C; 18 h;
参考文献
NOVARTIS AG; HÖGENAUER, Klemens; HURTH, Konstanze; KALIS, Christoph; MOEBITZ, Henrik; SOLDERMANN, Nicolas; ZECRI, Frédéric
Patent: WO2013/93850 A1, 2013 ;
Location in patent: Page/Page column 98 ;
