N-(6-溴噻唑并[5,4-b]吡啶-2-基)苯甲酰胺合成路线 （共 4 条）
反应条件
1: With sulfuric acid in water T=140°C; 1 h; 2: With sodium hydroxide in water pH=8;
参考文献
WO2009/74812 A1, ;
Page/Page column 91; 92 ;
WO 2009/074812 A1
反应条件
sodium methylate in 1-methyl-pyrrolidin-2-one
T=120°C; 4 h;
参考文献
Jouve, Karine; Bergman, Jan
Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 2 p. 261 - 268
反应条件
1.1: acetone / 0.08 h / Heating
1.2: 100 percent / acetone / 1 h / Heating
2.1: 67 percent / NaOMe / 1-methyl-pyrrolidin-2-one / 4 h / 120 °C
3.1: 78 percent / NaOMe / 1-methyl-pyrrolidin-2-one / 4 h / 120 °C
View Scheme
参考文献
Jouve, Karine; Bergman, Jan
Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 2 p. 261 - 268
反应条件
1: 67 percent / NaOMe / 1-methyl-pyrrolidin-2-one / 4 h / 120 °C
2: 78 percent / NaOMe / 1-methyl-pyrrolidin-2-one / 4 h / 120 °C
View Scheme
参考文献
Jouve, Karine; Bergman, Jan
Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 2 p. 261 - 268
