1,2-二甲氧基-4-乙基苯合成路线 （共 21 条）
反应条件
1,3-dimethyl-imidazolidin-2-one; sodium hexamethyldisilazane in tetrahydrofuran T=185°C; 12 h;
参考文献
Hwu, Jih Ru; Wong, Fung Fuh; Huang, Jiann-Jyh; Tsay, Shwu-Chen
Journal of Organic Chemistry, 1997 , vol. 62, # 12 p. 4097 - 4104
反应条件
1,3-dimethyl-imidazolidin-2-one; sodium hexamethyldisilazane in tetrahydrofuran T=185°C; 12 h;
参考文献
Hwu, Jih Ru; Wong, Fung Fuh; Huang, Jiann-Jyh; Tsay, Shwu-Chen
Journal of Organic Chemistry, 1997 , vol. 62, # 12 p. 4097 - 4104
反应条件
1,3-dimethyl-imidazolidin-2-one; lithium diisopropyl amide in tetrahydrofuran; n-heptane; ethylbenzene T=185°C; 12 h;
参考文献
Hwu, Jih Ru; Wong, Fung Fuh; Huang, Jiann-Jyh; Tsay, Shwu-Chen
Journal of Organic Chemistry, 1997 , vol. 62, # 12 p. 4097 - 4104
反应条件
hydrogen bromide; acetic acid in water
参考文献
Mitsui Toatsu Chemicals, Incorporated
Patent: US4985458 A1, 1991 ;
反应条件
4,4'-di-tert-butylbiphenyl; lithium; isopropyl alcohol; nickel dichloride in tetrahydrofuran
T=20 - 76°C; Inert atmosphere; chemoselective reaction;
参考文献
Takahashi, Tohru; Yoshimura, Masatoshi; Suzuka, Hiroyasu; Maegawa, Tomohiro; Sawama, Yoshinari; Monguchi, Yasunari; Sajiki, Hironao
Tetrahedron, 2012 , vol. 68, # 39 p. 8293 - 8299
反应条件
triethylsilane in trifluoroacetic acid
T=20°C; Reduction; 12 h;
参考文献
Ma, Tingli; Kojima, Takahiko; Matsuda, Yoshihisa
Bulletin of the Chemical Society of Japan, 2000 , vol. 73, # 3 p. 747 - 748
反应条件
lithium in diethyl ether; ethanol; ammonia
T=-33°C; 2 h;
参考文献
Yadav, J. S.; Reddy, P. Satyanarayana; Joshi, Bhalchandra V.
Tetrahedron, 1988 , vol. 44, # 23 p. 7243 - 7254
反应条件
triphenylphosphine; bis(1,5-cyclooctadiene)-rhodium(I) tetrafluoroborate in toluene
T=140°C; Cyclization; Anti-Markovnikov hydroamination; 48 h;
参考文献
Beller, Matthias; Thiel, Oliver R.; Trauthwein, Harald; Hartung, Christian G.
Chemistry - A European Journal, 2000 , vol. 6, # 14 p. 2513 - 2522
反应条件
1: 2-(3,4-dimethoxybenzyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane With Pd0(tris(tert-butyl)phosphine)2; cesium fluoride in water; N,N-dimethyl-formamide
T=120°C; 0.0166667 h; Inert atmosphereSchlenk technique;
2: methyl iodide in water; N,N-dimethyl-formamide
T=120°C; 0.0833333 h; Inert atmosphereSchlenk technique;
参考文献
Koyama, Hiroko; Zhang, Zhouen; Ijuin, Ryosuke; Siqin; Son, Jeongwan; Hatta, Yuma; Ohta, Masashi; Wakao, Masahiro; Hosoya, Takamitsu; Doi, Hisashi; Suzuki, Masaaki
RSC Advances, 2013 , vol. 3, # 24 p. 9391 - 9401
反应条件
triphenylphosphine; bis(1,5-cyclooctadiene)-rhodium(I) tetrafluoroborate in tetrahydrofuran
Substitution; Amination; Hydroamination; 20 h; Heating; Title compound not separated from byproducts;
参考文献
Beller; Trauthwein; Eichberger; Breindl; Herwig; Mueller; Thiel
Chemistry - A European Journal, 1999 , vol. 5, # 4 p. 1306 - 1319
